Detailed information of TA system TA108690

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1821214..1821851
• Replicon: chromosome
• Accession: NZ_CP031239
• Organism: Haemophilus influenzae strain M13034

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: A0A8G1T738
• Locus tag: DV369_RS08950
• Protein ID: WP_050948994.1
• Coordinates: 1821214..1821618 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: A0A0H3PN67
• Locus tag: DV369_RS08955
• Protein ID: WP_005656316.1
• Coordinates: 1821615..1821851 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV369_RS08930	1817695..1818279	-	585	WP_050948996.1	primosomal replication protein	-
DV369_RS08935	1818311..1819663	-	1353	WP_050948995.1	Na+/H+ antiporter family protein	-
DV369_RS08940	1819977..1820666	-	690	WP_021035684.1	ribonuclease T	-
DV369_RS08945	1820740..1821147	-	408	WP_005688980.1	lactoylglutathione lyase	-
DV369_RS08950	1821214..1821618	-	405	WP_050948994.1	type II toxin-antitoxin system VapC family toxin	Toxin
DV369_RS08955	1821615..1821851	-	237	WP_005656316.1	antitoxin	Antitoxin
DV369_RS08960	1821944..1822669	-	726	WP_021035687.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
DV369_RS08965	1822723..1823241	-	519	WP_005688985.1	isoprenylcysteine carboxyl methyltransferase family protein	-
DV369_RS08970	1823460..1825226	+	1767	WP_050948993.1	aspartate--tRNA ligase	-
DV369_RS08975	1825248..1825721	+	474	WP_050948992.1	dihydroneopterin triphosphate diphosphatase	-
DV369_RS08980	1825734..1826474	+	741	WP_005662961.1	YebC/PmpR family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15676.23 Da
• Isoelectric Point: 8.9777

>T108690 WP_050948994.1 NZ_CP031239:c1821618-1821214 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRVTDLQWQDWTK

Nucleotide

• Length: 405 bp

>T108690 NZ_CP031239:c1821618-1821214 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTAGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACGCATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTGTTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9007.16 Da
• Isoelectric Point: 4.2342

>AT108690 WP_005656316.1 NZ_CP031239:c1821851-1821615 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT108690 NZ_CP031239:c1821851-1821615 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3PN67