Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1035414..1035949 Replicon chromosome
Accession NZ_CP031239
Organism Haemophilus influenzae strain M13034

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DV369_RS05205 Protein ID WP_050948472.1
Coordinates 1035686..1035949 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8G1T6U5
Locus tag DV369_RS05200 Protein ID WP_050948473.1
Coordinates 1035414..1035689 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV369_RS05185 1032648..1033289 + 642 Protein_988 ESPR domain-containing protein -
DV369_RS05190 1033465..1034439 - 975 WP_050948474.1 zinc transporter permease subunit ZevB -
DV369_RS05195 1034442..1035062 - 621 WP_050846950.1 zinc transporter binding subunit ZevA -
DV369_RS05200 1035414..1035689 + 276 WP_050948473.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DV369_RS05205 1035686..1035949 + 264 WP_050948472.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DV369_RS05210 1036044..1037714 + 1671 WP_050848571.1 energy-dependent translational throttle protein EttA -
DV369_RS05215 1037776..1038117 + 342 WP_050846956.1 SirB2 family protein -
DV369_RS05220 1038122..1040092 + 1971 WP_050948471.1 tRNA(Met) cytidine acetyltransferase TmcA -
DV369_RS09325 1040089..1040262 + 174 WP_005657572.1 DUF5363 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10216.87 Da        Isoelectric Point: 6.8597

>T108689 WP_050948472.1 NZ_CP031239:1035686-1035949 [Haemophilus influenzae]
MISVSGEYKREFKEHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

>T108689 NZ_CP031239:1035686-1035949 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAGAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCACGCTTTAACTGGCAATTGGAAAGGTT
GGCGAGATTGCCATATTAAGAATGATCTCGTGCTTATTTATAAAATTGTGGGGGATGAAATAAGACTAGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10271.82 Da        Isoelectric Point: 5.6663

>AT108689 WP_050948473.1 NZ_CP031239:1035414-1035689 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHNGREYKTLEE
FHQAMLSEMKS

Download         Length: 276 bp

>AT108689 NZ_CP031239:1035414-1035689 [Haemophilus influenzae]
ATGGCTGCAGTTAGCTTTCGAGTACCTGATGAAACTAAAAATATAGCGTTTGAAGTGATTAAAAGTTATGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTGGATAATCATAATGGGCGTGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTATCGGAGATGAAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References