Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 463561..464039 Replicon chromosome
Accession NZ_CP031239
Organism Haemophilus influenzae strain M13034

Toxin (Protein)


Gene name VapD Uniprot ID A0A0K9L551
Locus tag DV369_RS02315 Protein ID WP_050848517.1
Coordinates 463761..464039 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag DV369_RS02310 Protein ID WP_012055040.1
Coordinates 463561..463752 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV369_RS02285 459141..459773 + 633 WP_050948790.1 dTMP kinase -
DV369_RS02290 459770..460753 + 984 WP_114893716.1 DNA polymerase III subunit delta' -
DV369_RS02295 460808..461590 + 783 WP_005662581.1 YchF/TatD family DNA exonuclease -
DV369_RS02300 461617..462141 + 525 WP_005656502.1 DUF1523 family protein -
DV369_RS02305 462192..463490 + 1299 WP_075985482.1 hemolysin family protein -
DV369_RS02310 463561..463752 + 192 WP_012055040.1 DUF5397 family protein Antitoxin
DV369_RS02315 463761..464039 + 279 WP_050848517.1 virulence-associated protein VapD Toxin
DV369_RS02320 464135..464665 + 531 WP_050948746.1 hypothetical protein -
DV369_RS02325 464737..466236 + 1500 WP_050948745.1 fused PTS fructose transporter subunit IIA/HPr protein -
DV369_RS02330 466238..467179 + 942 WP_050948744.1 1-phosphofructokinase -
DV369_RS02335 467181..468851 + 1671 WP_050948743.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10604.98 Da        Isoelectric Point: 5.7408

>T108688 WP_050848517.1 NZ_CP031239:463761-464039 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNSLKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Download         Length: 279 bp

>T108688 NZ_CP031239:463761-464039 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAAGGTGTTCAGCAGGCTTATACAGA
CATTGGTGCGGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATACAAATGAAGATATGGCAA
ACCTTTTTCAGGCAATGAATTCGCTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGACTTCACTGACTTTATACGAAGTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT108688 WP_012055040.1 NZ_CP031239:463561-463752 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT108688 NZ_CP031239:463561-463752 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACGGGCTGTATTAAACAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGATATTTATCGCTTAT
CTCACTTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L551

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References