Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 398008..398612 Replicon chromosome
Accession NZ_CP031239
Organism Haemophilus influenzae strain M13034

Toxin (Protein)


Gene name relE Uniprot ID A0A2S9RBL9
Locus tag DV369_RS02015 Protein ID WP_050948779.1
Coordinates 398008..398316 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag DV369_RS02020 Protein ID WP_005692346.1
Coordinates 398316..398612 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV369_RS02005 393076..394374 - 1299 WP_050948913.1 trigger factor -
DV369_RS02010 394704..397949 + 3246 WP_114893715.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DV369_RS02015 398008..398316 - 309 WP_050948779.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DV369_RS02020 398316..398612 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DV369_RS02025 398732..399586 - 855 WP_050948778.1 DUF3298 domain-containing protein -
DV369_RS02030 399605..401464 - 1860 WP_050948777.1 selenocysteine-specific translation elongation factor -
DV369_RS02035 401461..402846 - 1386 WP_050948776.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-99)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11949.72 Da        Isoelectric Point: 7.8657

>T108687 WP_050948779.1 NZ_CP031239:c398316-398008 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

>T108687 NZ_CP031239:c398316-398008 [Haemophilus influenzae]
ATGTCAGAAGAGAAGCCATTAAAAGTAAGCTATTCAAAACAATTTGTAAGAGATTTAACTGATTTAGCTAAACGCTCCCC
CAATGTGTTAATTGGCTCAAAATACATTACTGCAATATACTGTTTATTAAATCGTTTACCTTTACCCGAAAACTACCAAG
ATCACGCATTAGTAGGAGAGTGGAAAGGTTATCGAGATTGCCATATTCAAGGCGATTTGGTACTGATTTACCAATACGTT
ATACGCGATGAATTTGATGAATTGAAATTTTCTCGTTTAAATACACACTCACAAACCGCTTTAAAATAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT108687 WP_005692346.1 NZ_CP031239:c398612-398316 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp

>AT108687 NZ_CP031239:c398612-398316 [Haemophilus influenzae]
ATGGCACTTACGAATTCCTCTATCAGCTTTAGAACAGTTGAGCAAACAAAATCAGAAGCTTATCAAGTTATTGAACAATA
TGGACTTACCCCATCACAAGTATTCAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTATTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATTGATGAATTAGATAGTGGTAACGCAGAGAGCTTTTTTATTGAAGCT
AGTGAAAATTATTCTGCCGAAGAATTTACAAAACGCATTCTTAATGGTGGTCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9RBL9

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References