Detailed information of TA system TA108685

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 312980..313454
• Replicon: chromosome
• Accession: NZ_CP031239
• Organism: Haemophilus influenzae strain M13034

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: -
• Locus tag: DV369_RS01615
• Protein ID: WP_197733310.1
• Coordinates: 313269..313454 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: DV369_RS01610
• Protein ID: WP_005650837.1
• Coordinates: 312980..313276 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV369_RS01585	308391..308948	-	558	WP_050949054.1	DNA-3-methyladenine glycosylase I	-
DV369_RS01590	308945..309763	-	819	WP_050949053.1	shikimate dehydrogenase	-
DV369_RS01595	309767..310318	-	552	WP_050949052.1	Sua5/YciO/YrdC/YwlC family protein	-
DV369_RS01600	310334..310870	-	537	WP_050949051.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
DV369_RS01605	310880..312796	-	1917	WP_050949050.1	ABC transporter ATP-binding protein	-
DV369_RS01610	312980..313276	-	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
DV369_RS01615	313269..313454	-	186	WP_197733310.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV369_RS01620	313597..316619	-	3023	Protein_292	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (2-51)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7462.80 Da
• Isoelectric Point: 11.0200

>T108685 WP_197733310.1 NZ_CP031239:c313454-313269 [Haemophilus influenzae]
ILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 186 bp

>T108685 NZ_CP031239:c313454-313269 [Haemophilus influenzae]
ATTTTAGACGGTGAAATTTGGGAACTTCGCCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGT
CTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACTGCCCAACAACGCTTAAGTGAAT
TAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT108685 WP_005650837.1 NZ_CP031239:c313276-312980 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT108685 NZ_CP031239:c313276-312980 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCCTTGGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA