Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 236094..236629 Replicon chromosome
Accession NZ_CP031238
Organism Haemophilus haemolyticus strain M28486

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DV441_RS01025 Protein ID WP_114892315.1
Coordinates 236094..236357 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DV441_RS01030 Protein ID WP_114892316.1
Coordinates 236354..236629 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV441_RS08850 231907..232080 - 174 WP_162790460.1 DUF5363 family protein -
DV441_RS01010 232077..233921 - 1845 WP_114892312.1 tRNA(Met) cytidine acetyltransferase TmcA -
DV441_RS01015 233926..234267 - 342 WP_114892313.1 SirB2 family protein -
DV441_RS01020 234329..235999 - 1671 WP_114892314.1 energy-dependent translational throttle protein EttA -
DV441_RS01025 236094..236357 - 264 WP_114892315.1 type II toxin-antitoxin system YafQ family toxin Toxin
DV441_RS01030 236354..236629 - 276 WP_114892316.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DV441_RS01035 236980..237600 + 621 WP_114892317.1 zinc transporter binding subunit ZevA -
DV441_RS01040 237603..238571 + 969 WP_114892318.1 zinc transporter permease subunit ZevB -
DV441_RS01050 238977..239633 + 657 WP_114892319.1 hypothetical protein -
DV441_RS01055 239939..240982 + 1044 WP_162790461.1 YadA-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10249.99 Da        Isoelectric Point: 8.4694

>T108684 WP_114892315.1 NZ_CP031238:c236357-236094 [Haemophilus haemolyticus]
MISVSGEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGYEIRLARLN
THSEIFG

Download         Length: 264 bp

>T108684 NZ_CP031238:c236357-236094 [Haemophilus haemolyticus]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGATATGAAATAAGGCTAGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10236.77 Da        Isoelectric Point: 5.5759

>AT108684 WP_114892316.1 NZ_CP031238:c236629-236354 [Haemophilus haemolyticus]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHNGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp

>AT108684 NZ_CP031238:c236629-236354 [Haemophilus haemolyticus]
ATGGCTGCAGTTAGTTTTCGAGTACCTGATGAAACTAAAAATATAGCGTTTGAAGTGATTAAAAGTTATGGGCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTAGATAATCATAATGGGCATGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTAGCGGAGATGAAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References