Detailed information of TA system TA108683

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 103621..105179
• Replicon: chromosome
• Accession: NZ_CP031238
• Organism: Haemophilus haemolyticus strain M28486

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: DV441_RS00420
• Protein ID: WP_080948091.1
• Coordinates: 103899..105179 (+)
• Length: 427 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0M3G8E2
• Locus tag: DV441_RS00415
• Protein ID: WP_012771639.1
• Coordinates: 103621..103899 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV441_RS00390	98997..100223	+	1227	WP_114892277.1	Ni/Fe-hydrogenase cytochrome b subunit	-
DV441_RS00395	100223..101932	+	1710	WP_005645350.1	hydrogenase 2 large subunit	-
DV441_RS00400	101932..102405	+	474	WP_046939475.1	HyaD/HybD family hydrogenase maturation endopeptidase	-
DV441_RS00405	102497..103006	+	510	WP_046952853.1	hydrogenase-2 assembly chaperone	-
DV441_RS00410	103036..103311	+	276	WP_005626486.1	hydrogenase maturation factor HybG	-
DV441_RS00415	103621..103899	+	279	WP_012771639.1	helix-turn-helix domain-containing protein	Antitoxin
DV441_RS00420	103899..105179	+	1281	WP_080948091.1	type II toxin-antitoxin system HipA family toxin	Toxin
DV441_RS00425	105197..107500	-	2304	WP_114892278.1	DUF2357 domain-containing protein	-
DV441_RS00430	107506..109113	-	1608	WP_205334689.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 427 a.a.
• Molecular weight: 49071.21 Da
• Isoelectric Point: 7.8006

>T108683 WP_080948091.1 NZ_CP031238:103899-105179 [Haemophilus haemolyticus]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGENRSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSSSSENEWLCLNIMKALGLPVPRSQIQYFGEIKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLNGSSNAQADRKQFFKAQIVFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKYNGLQKQKVKMAMAWHGENKHYLWDKIQLRHIFNTAKLAGLAKETVEDTLHEISALYPRVSE
INTHGLPDDIVESIFMGLEMQMKKIS

Nucleotide

• Length: 1281 bp

>T108683 NZ_CP031238:103899-105179 [Haemophilus haemolyticus]
ATGAGTAACTCGATTCTAAACGTTGCTATGAATGGCTTGTTAGTCGGTGAATGGCGAAAACTCACCAGTGGCGCAACCGA
ATTTCAGTATGCGGAAAAATGGCTTGAATCTGTTCGCTCGCGCCCTATTTCATTGTCACTGCCCTTGTCGCACAAAATTT
ATCGAGGAGATTCCGTTTACAATTTCTTCGATAATCTGCTCCCAGACAACGAACAGATCCGTTCACGCATTCAACAACGT
TTCCAAACATCAACGAAATCCCCATTTGATTTGCTTTCTGCGATTGGACAGGATTGTATCGGTGCAATTCAACTTTATCA
GGGCGAGAACCGCTCGGTGCGTCAAATTTATGCAGAACCACTAAATGACAAAGAGGTGGAAAACGTGCTGAAAAACTACC
GCACTTTTCCTCTCGGCATGGAAGAAAGCGAGGATTTCCGAATTTCTTTGGCCGGCGCTCAGGAAAAAACAGCGCTGCTT
TATTATCAGAATCAATGGCAGCGCCCTTTGCATTCCACCGCGACCAGCCATATTTTTAAACTCCCGATTGGTATGGTGGC
ACAAGGGCAACTTGATCTTTCCAGCAGCAGTGAAAATGAATGGCTTTGCTTGAATATTATGAAAGCCTTAGGTTTGCCGG
TTCCTCGAAGCCAAATTCAGTATTTCGGTGAAATTAAAGTACTGATTGTGGAACGCTTTGATCGCCGTTGGTCTGAAAAT
AGGAGTTGGCTAATTCGTTTACCACAGGAAGATATGTGCCAAGCACTCAACATCGCCCCTGCGCGAAAATATGAAAATGA
CGGCGGGCCGAGCATTCTTCAAATTATGTCGCTTCTCAACGGTTCATCCAACGCCCAAGCAGATCGCAAGCAGTTTTTTA
AAGCGCAAATTGTTTTCTGGCTACTTTGTGCTATTGACGGCCATGGCAAAAATTTCAGTTTATTTTTGGAACAAGAGAAT
CGCTATCGTCTAACACCTTTTTACGACGTCATGTCCGCCTATCCACTTATCAAATATAACGGACTACAAAAGCAAAAAGT
CAAAATGGCAATGGCGTGGCACGGCGAAAATAAACATTATTTATGGGATAAAATACAACTCCGCCACATTTTCAATACCG
CTAAACTCGCAGGCTTGGCAAAGGAAACAGTAGAAGATACTTTGCATGAGATCAGTGCACTATATCCAAGAGTCAGTGAA
ATAAATACTCATGGATTGCCTGATGACATTGTCGAGTCTATTTTCATGGGATTAGAAATGCAGATGAAAAAGATAAGTTA
A

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10414.83 Da
• Isoelectric Point: 5.1651

>AT108683 WP_012771639.1 NZ_CP031238:103621-103899 [Haemophilus haemolyticus]
MVITTAKMLSHVIREFRYQGDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSDTARSIK
EPTATYDDDEAW

Nucleotide

• Length: 279 bp

>AT108683 NZ_CP031238:103621-103899 [Haemophilus haemolyticus]
ATGGTTATCACCACCGCAAAAATGCTTTCTCATGTAATTCGAGAATTTCGCTATCAAGGCGATCTGTCACAAACTGATGT
TGCTAAACTCGCCGGAACAACCCAAGCCAGAATTTCAGCGTTTGAGAATGAGCCGGAGCGTACTAAATTAGAAACACTAT
TTAAAATTCTGGCAGGATTAGAATTAGAGCTTATTGTACAACCACGCAAAAAGTCATCTGATACTGCCCGTTCAATCAAG
GAGCCTACAGCAACATACGATGACGACGAGGCATGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0M3G8E2