Detailed information of TA system TA108682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1710045..1710516
• Replicon: chromosome
• Accession: NZ_CP031237
• Organism: Haemophilus influenzae strain M12125

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A806DTA9
• Locus tag: DV365_RS08390
• Protein ID: WP_005654546.1
• Coordinates: 1710045..1710227 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: DV365_RS08395
• Protein ID: WP_005650837.1
• Coordinates: 1710220..1710516 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV365_RS08385	1706821..1709784	+	2964	WP_114890681.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
DV365_RS08390	1710045..1710227	+	183	WP_005654546.1	shikimate 5-dehydrogenase	Toxin
DV365_RS08395	1710220..1710516	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
DV365_RS08400	1710677..1712593	+	1917	WP_105905590.1	ABC transporter ATP-binding protein	-
DV365_RS08405	1712603..1713139	+	537	WP_038439524.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
DV365_RS08410	1713155..1713706	+	552	WP_038439523.1	Sua5/YciO/YrdC/YwlC family protein	-
DV365_RS08415	1713710..1714516	+	807	WP_105905591.1	shikimate dehydrogenase	-
DV365_RS08420	1714730..1715293	+	564	WP_021034570.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7318.33 Da
• Isoelectric Point: 6.3057

>T108682 WP_005654546.1 NZ_CP031237:1710045-1710227 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Nucleotide

• Length: 183 bp

>T108682 NZ_CP031237:1710045-1710227 [Haemophilus influenzae]
ATGTACGAGATTCTCTTTTACAGAGACCAAAATGACATTGAGCCAGTGAAAGAGTATCTGCTATCTCTGGCTCAAAATGA
AAGCAAAGATAGTCGAATTAAACTGAATAAAATTCGAGATTATGTAATCCAAACTGCCCAACAACGCTTAAGTGAATTAA
AAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT108682 WP_005650837.1 NZ_CP031237:1710220-1710516 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT108682 NZ_CP031237:1710220-1710516 [Haemophilus influenzae]
ATGAATAAAATTAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGAGAAAG
TAATTTACGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAGCTTGAAACGTTGTTAAAATTG
CTCGCTCCTTTAGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA

Structures

Toxin

• AlphaFold DB: A0A806DTA9