Detailed information of TA system TA108676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1859000..1859474
• Replicon: chromosome
• Accession: NZ_CP031236
• Organism: Haemophilus influenzae strain M25267

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: -
• Locus tag: DV400_RS09200
• Protein ID: WP_197733310.1
• Coordinates: 1859000..1859185 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: DV400_RS09205
• Protein ID: WP_005650837.1
• Coordinates: 1859178..1859474 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV400_RS09195	1855767..1858857	+	3091	Protein_1754	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
DV400_RS09200	1859000..1859185	+	186	WP_197733310.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV400_RS09205	1859178..1859474	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
DV400_RS09210	1859658..1861574	+	1917	WP_114892243.1	ABC transporter ATP-binding protein	-
DV400_RS09215	1861584..1862120	+	537	WP_050949051.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
DV400_RS09220	1862136..1862687	+	552	WP_050949052.1	Sua5/YciO/YrdC/YwlC family protein	-
DV400_RS09225	1862691..1863509	+	819	WP_050949053.1	shikimate dehydrogenase	-
DV400_RS09230	1863506..1864063	+	558	WP_050949054.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (2-51)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7462.80 Da
• Isoelectric Point: 11.0200

>T108676 WP_197733310.1 NZ_CP031236:1859000-1859185 [Haemophilus influenzae]
ILDGEIWELRPIRDRILFARLMDGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 186 bp

>T108676 NZ_CP031236:1859000-1859185 [Haemophilus influenzae]
ATTTTAGACGGTGAAATTTGGGAACTTCGCCCAATTAGGGATCGCATCTTGTTTGCAAGATTAATGGACGGTCGCTTTGT
CTTACTACATCAATTTATGAAGAAAACACAAAAAACGCCAAAACGAGAAATCCAAACTGCCCAACAACGCTTAAGTGAAT
TAAAAGAGAGATTGAAAAATGAATAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT108676 WP_005650837.1 NZ_CP031236:1859178-1859474 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT108676 NZ_CP031236:1859178-1859474 [Haemophilus influenzae]
ATGAATAAAATCAGCCCATTAGGTTCAAATTGGAATGAGTTTGAACAGCAAATTTTCAATGAAGAAGAAATCCGCGAAAG
TAATTTGCGTGTAGCCTTAATTAAAGAATTGATTACTTCTCGCCAGCAACTTGGGATTTCCCAAAAACAACTTGAAACCT
TAAGCGGTGTGAAGCAACCTATGATTGCACGCATTGAAAAAGGACAAACGAATCCTCAACTTGAAACGTTGTTAAAATTG
CTCGCTCCCTTGGGGAAAACCCTGTCGATTGTGCCTCTAAGGGTAAAAAATGCCTAA