Detailed information of TA system TA108673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapXD/-
• Location: 1709982..1710460
• Replicon: chromosome
• Accession: NZ_CP031236
• Organism: Haemophilus influenzae strain M25267

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: -
• Locus tag: DV400_RS08505
• Protein ID: WP_114892238.1
• Coordinates: 1709982..1710260 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: VapX
• Uniprot ID: A0A0K9KX05
• Locus tag: DV400_RS08510
• Protein ID: WP_012055040.1
• Coordinates: 1710269..1710460 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV400_RS08485	1705170..1706840	-	1671	WP_050948743.1	fructose-specific PTS transporter subunit EIIC	-
DV400_RS08490	1706842..1707783	-	942	WP_050948744.1	1-phosphofructokinase	-
DV400_RS08495	1707785..1709284	-	1500	WP_050948745.1	fused PTS fructose transporter subunit IIA/HPr protein	-
DV400_RS08500	1709356..1709886	-	531	WP_050948746.1	hypothetical protein	-
DV400_RS08505	1709982..1710260	-	279	WP_114892238.1	virulence factor	Toxin
DV400_RS08510	1710269..1710460	-	192	WP_012055040.1	DUF5397 family protein	Antitoxin
DV400_RS08515	1710531..1711829	-	1299	WP_050948747.1	hemolysin family protein	-
DV400_RS08520	1711880..1712404	-	525	WP_050948748.1	DUF1523 family protein	-
DV400_RS08525	1712431..1713213	-	783	WP_050948749.1	YchF/TatD family DNA exonuclease	-
DV400_RS08530	1713252..1714232	-	981	WP_050948750.1	DNA polymerase III subunit delta'	-
DV400_RS08535	1714229..1714861	-	633	WP_050948790.1	dTMP kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-86)

Antitoxin

• Protein of unknown function DUF5397 (1-63)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10592.92 Da
• Isoelectric Point: 5.7408

>T108673 WP_114892238.1 NZ_CP031236:c1710260-1709982 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDTGAVLAKFGFVRTQGSLYTNTNEDMANLFQAMNSLKQLAWISQSVRDIRAFRI
EQWSDFTDFIRS

Nucleotide

• Length: 279 bp

>T108673 NZ_CP031236:c1710260-1709982 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAAGGTGTTCAGCAGGCTTATACAGA
CACTGGTGCGGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATACAAATGAAGATATGGCAA
ACCTTTTTCAGGCAATGAATTCGCTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGACTTCACTGACTTTATACGAAGTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7018.97 Da
• Isoelectric Point: 3.9930

>AT108673 WP_012055040.1 NZ_CP031236:c1710460-1710269 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Nucleotide

• Length: 192 bp

>AT108673 NZ_CP031236:c1710460-1710269 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACGGGCTGTATTAAACAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGATATTTATCGCTTAT
CTCACTTACTTGAAGATCCCGAAGCTGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0K9KX05