Detailed information of TA system TA108672

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1104498..1105033
• Replicon: chromosome
• Accession: NZ_CP031236
• Organism: Haemophilus influenzae strain M25267

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A852PXV4
• Locus tag: DV400_RS05380
• Protein ID: WP_061671384.1
• Coordinates: 1104498..1104761 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8G1T6U5
• Locus tag: DV400_RS05385
• Protein ID: WP_050948473.1
• Coordinates: 1104758..1105033 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV400_RS09535	1100185..1100358	-	174	WP_005657572.1	DUF5363 domain-containing protein	-
DV400_RS05365	1100355..1102325	-	1971	WP_050948471.1	tRNA(Met) cytidine acetyltransferase TmcA	-
DV400_RS05370	1102330..1102671	-	342	WP_050846956.1	SirB2 family protein	-
DV400_RS05375	1102733..1104403	-	1671	WP_050848571.1	energy-dependent translational throttle protein EttA	-
DV400_RS05380	1104498..1104761	-	264	WP_061671384.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
DV400_RS05385	1104758..1105033	-	276	WP_050948473.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
DV400_RS05390	1105385..1106005	+	621	WP_050846950.1	zinc transporter binding subunit ZevA	-
DV400_RS05395	1106008..1106982	+	975	WP_050948474.1	zinc transporter permease subunit ZevB	-
DV400_RS05400	1107158..1107799	-	642	Protein_1011	ESPR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-87)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10215.93 Da
• Isoelectric Point: 7.8978

>T108672 WP_061671384.1 NZ_CP031236:c1104761-1104498 [Haemophilus influenzae]
MISVSGEYKREFKKHIPLIINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKIVGDEIRLARLN
THSEIFG

Nucleotide

• Length: 264 bp

>T108672 NZ_CP031236:c1104761-1104498 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCACGCTTTAACTGGCAATTGGAAAGGTT
GGCGAGATTGCCATATTAAGAATGATCTCGTGCTTATTTATAAAATTGTGGGGGATGAAATAAGACTAGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10271.82 Da
• Isoelectric Point: 5.6663

>AT108672 WP_050948473.1 NZ_CP031236:c1105033-1104758 [Haemophilus influenzae]
MAAVSFRVPDETKNIAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHNGREYKTLEE
FHQAMLSEMKS

Nucleotide

• Length: 276 bp

>AT108672 NZ_CP031236:c1105033-1104758 [Haemophilus influenzae]
ATGGCTGCAGTTAGCTTTCGAGTACCTGATGAAACTAAAAATATAGCGTTTGAAGTGATTAAAAGTTATGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTGGATAATCATAATGGGCGTGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTATCGGAGATGAAATCATGA

Structures

Toxin

• AlphaFold DB: A0A852PXV4