Detailed information of TA system TA108671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 290929..291566
• Replicon: chromosome
• Accession: NZ_CP031236
• Organism: Haemophilus influenzae strain M25267

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: -
• Locus tag: DV400_RS01505
• Protein ID: WP_114892218.1
• Coordinates: 291162..291566 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: A0A0H3PN67
• Locus tag: DV400_RS01500
• Protein ID: WP_005656316.1
• Coordinates: 290929..291165 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV400_RS01475	286306..287046	-	741	WP_005662961.1	YebC/PmpR family DNA-binding transcriptional regulator	-
DV400_RS01480	287059..287532	-	474	WP_050948992.1	dihydroneopterin triphosphate diphosphatase	-
DV400_RS01485	287554..289320	-	1767	WP_050948993.1	aspartate--tRNA ligase	-
DV400_RS01490	289539..290057	+	519	WP_005688985.1	isoprenylcysteine carboxyl methyltransferase family protein	-
DV400_RS01495	290111..290836	+	726	WP_021035687.1	carboxy-S-adenosyl-L-methionine synthase CmoA	-
DV400_RS01500	290929..291165	+	237	WP_005656316.1	antitoxin	Antitoxin
DV400_RS01505	291162..291566	+	405	WP_114892218.1	type II toxin-antitoxin system VapC family toxin	Toxin
DV400_RS01510	291633..292040	+	408	WP_005688980.1	lactoylglutathione lyase	-
DV400_RS01515	292114..292803	+	690	WP_021035684.1	ribonuclease T	-
DV400_RS01520	293117..294469	+	1353	WP_050948995.1	Na+/H+ antiporter family protein	-
DV400_RS01525	294501..295085	+	585	WP_050948996.1	primosomal replication protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (6-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15706.26 Da
• Isoelectric Point: 8.9777

>T108671 WP_114892218.1 NZ_CP031236:291162-291566 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFSSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHTLSLNAVLITHNVKEFQRVTDLQWQDWTK

Nucleotide

• Length: 405 bp

>T108671 NZ_CP031236:291162-291566 [Haemophilus influenzae]
ATGATTTATATGTTAGACACCAATATCATTATTTATTTAATGAAAAATCGCCCCAAAATTGTTGCCGAACGAGTATCACA
ATTATTGCCTAATGATCGCTTAGTTATCAGCTTTATTACTTATGCTGAACTTATTAAAGGCGCCTTTAGTAGTCAAAATT
ATGAGCAATCAATACGAGCAATAGAATTACTTACTGAACGAGTAAATGTACTATATCCCAATGAACAAATCTGTTTACAT
TATGGCAAATGGGCAAATACACTCAAAAAACAAGGGAGACCTATCGGAAATAATGATCTATGGATTGCTTGTCACACATT
GAGTTTAAATGCTGTTCTTATTACACATAATGTAAAAGAATTTCAGCGTGTTACAGATCTTCAGTGGCAAGATTGGACAA
AATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9007.16 Da
• Isoelectric Point: 4.2342

>AT108671 WP_005656316.1 NZ_CP031236:290929-291165 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Nucleotide

• Length: 237 bp

>AT108671 NZ_CP031236:290929-291165 [Haemophilus influenzae]
ATGCTTGCTAAAGTGTTTCAAAGTGGTAACAGCCAAGCTGTTCGGATCCCGATGGACTTTCGTTTTGATGTCGATACCGT
AGAAATTTTCCGAAAGGAAAATGGGGATGTGGTATTACGCCCAGTTTCTAAAAAAACAGATGATTTTCTTGCGTTATTTG
AAGGATTTGATGAGACCTTTATTCAAGCACTTGAAGCGCGTGATGATTTACCGCCTCAGGAGCGAGAAAATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3PN67