Detailed information of TA system TA108641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 2899113..2899633
• Replicon: chromosome
• Accession: NZ_CP031229
• Organism: Ornithinimicrobium sp. AMA3305

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DV701_RS13200
• Protein ID: WP_114928885.1
• Coordinates: 2899376..2899633 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DV701_RS13195
• Protein ID: WP_114931136.1
• Coordinates: 2899113..2899376 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV701_RS13165	2894930..2895202	+	273	WP_114928879.1	hypothetical protein	-
DV701_RS13170	2895266..2895970	-	705	WP_114928880.1	hypothetical protein	-
DV701_RS13175	2896027..2896257	+	231	WP_114928881.1	ribbon-helix-helix domain-containing protein	-
DV701_RS13180	2896244..2896591	+	348	WP_114928882.1	type II toxin-antitoxin system PemK/MazF family toxin	-
DV701_RS13185	2896866..2898044	+	1179	WP_114928883.1	IS110 family transposase	-
DV701_RS13190	2898077..2898646	-	570	WP_114928884.1	hypothetical protein	-
DV701_RS13195	2899113..2899376	+	264	WP_114931136.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DV701_RS13200	2899376..2899633	+	258	WP_114928885.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV701_RS13205	2901157..2901864	+	708	WP_162803027.1	hypothetical protein	-
DV701_RS13210	2902064..2902270	+	207	WP_114928887.1	hypothetical protein	-
DV701_RS13215	2902486..2903792	-	1307	Protein_2595	ISL3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2889940..2919855	29915
	-	flank	IS/Tn	-	-	2902486..2903523	1037

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-68)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9801.26 Da
• Isoelectric Point: 10.0898

>T108641 WP_114928885.1 NZ_CP031229:2899376-2899633 [Ornithinimicrobium sp. AMA3305]
MTEQYEVAWTPTAKRALQRLPEKVATAAIEFIYGPLASNPQRVGKALRFDLEGLHSARRGSYRIIYRIDERVTVIAIEHR
ADVYR

Nucleotide

• Length: 258 bp

>T108641 NZ_CP031229:2899376-2899633 [Ornithinimicrobium sp. AMA3305]
ATGACGGAGCAGTACGAGGTCGCGTGGACGCCTACGGCCAAGCGCGCTCTGCAGCGACTGCCCGAAAAAGTGGCCACGGC
GGCCATCGAGTTCATCTACGGCCCACTCGCGAGCAATCCCCAGCGCGTCGGCAAAGCCTTGCGCTTCGACCTCGAAGGAC
TGCACAGCGCACGACGCGGCTCGTACAGGATCATCTACCGGATCGATGAGCGCGTGACCGTCATTGCGATCGAGCACCGC
GCAGACGTCTACCGATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9711.12 Da
• Isoelectric Point: 5.1976

>AT108641 WP_114931136.1 NZ_CP031229:2899113-2899376 [Ornithinimicrobium sp. AMA3305]
MALRDVKNRLSEVVDQVEREHDRVVITRHGKPVAVVISADDLESLEETLKVVSRPRLISQVRDSLAELVAGEAEALSKED
ILARLRA

Nucleotide

• Length: 264 bp

>AT108641 NZ_CP031229:2899113-2899376 [Ornithinimicrobium sp. AMA3305]
ATGGCCCTGCGTGATGTGAAGAATCGCCTGTCCGAGGTGGTGGACCAGGTCGAGCGCGAGCATGACCGGGTGGTGATCAC
TCGGCACGGCAAGCCGGTGGCTGTGGTGATCAGCGCCGATGACCTCGAGTCGTTGGAGGAGACGCTGAAGGTCGTGAGCC
GACCAAGACTCATCAGTCAGGTCCGAGACAGCCTTGCCGAGCTCGTGGCTGGCGAGGCCGAGGCCCTCAGCAAGGAGGAC
ATTCTTGCGAGGCTGCGCGCCTGA