Detailed information of TA system TA108640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2896027..2896591
• Replicon: chromosome
• Accession: NZ_CP031229
• Organism: Ornithinimicrobium sp. AMA3305

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DV701_RS13180
• Protein ID: WP_114928882.1
• Coordinates: 2896244..2896591 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: DV701_RS13175
• Protein ID: WP_114928881.1
• Coordinates: 2896027..2896257 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV701_RS13135	2891063..2891503	-	441	WP_162803026.1	hypothetical protein	-
DV701_RS13140	2891695..2891997	+	303	WP_114928877.1	hypothetical protein	-
DV701_RS13145	2892040..2892324	-	285	WP_022920210.1	hypothetical protein	-
DV701_RS13150	2892477..2892785	+	309	WP_022920209.1	LysR family transcriptional regulator substrate-binding protein	-
DV701_RS13155	2892997..2893602	-	606	WP_084617068.1	Lrp/AsnC family transcriptional regulator	-
DV701_RS13160	2893601..2894632	+	1032	WP_114928878.1	pyridoxal-phosphate dependent enzyme	-
DV701_RS13165	2894930..2895202	+	273	WP_114928879.1	hypothetical protein	-
DV701_RS13170	2895266..2895970	-	705	WP_114928880.1	hypothetical protein	-
DV701_RS13175	2896027..2896257	+	231	WP_114928881.1	ribbon-helix-helix domain-containing protein	Antitoxin
DV701_RS13180	2896244..2896591	+	348	WP_114928882.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DV701_RS13185	2896866..2898044	+	1179	WP_114928883.1	IS110 family transposase	-
DV701_RS13190	2898077..2898646	-	570	WP_114928884.1	hypothetical protein	-
DV701_RS13195	2899113..2899376	+	264	WP_114931136.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DV701_RS13200	2899376..2899633	+	258	WP_114928885.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2889940..2919855	29915

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12561.53 Da
• Isoelectric Point: 10.6350

>T108640 WP_114928882.1 NZ_CP031229:2896244-2896591 [Ornithinimicrobium sp. AMA3305]
MLRGEILLVDLDPVRGSEANKRRPAVLVSNDRANTMAERLGRGVVTVVPVTSNVERIFPFQVLLPADETGLRVDSKAQAE
QVRSVAVERVGSAVGRVSHRLMAAVDEALRIHLQL

Nucleotide

• Length: 348 bp

>T108640 NZ_CP031229:2896244-2896591 [Ornithinimicrobium sp. AMA3305]
ATGCTGCGCGGTGAGATCCTTCTCGTCGATCTGGATCCGGTGCGCGGCAGCGAGGCCAACAAGCGGCGGCCCGCGGTGCT
CGTCAGCAATGATCGGGCGAACACCATGGCTGAACGACTCGGTCGTGGAGTAGTCACCGTCGTGCCCGTGACCAGCAACG
TGGAGCGGATCTTCCCGTTCCAGGTGTTGCTGCCAGCCGACGAGACAGGACTGCGGGTGGACTCCAAGGCCCAGGCGGAG
CAGGTGCGCTCCGTCGCAGTCGAGCGGGTCGGTTCTGCGGTAGGCCGGGTGTCGCACCGCCTTATGGCCGCGGTCGACGA
AGCGTTGCGAATCCATCTGCAACTGTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8182.90 Da
• Isoelectric Point: 3.8705

>AT108640 WP_114928881.1 NZ_CP031229:2896027-2896257 [Ornithinimicrobium sp. AMA3305]
MKVSVSLSEQDLAALDRYVEEAGLESRSAAVQQAIRRLQDPQLEAAYAAAWEEWAVAGDEDAWASTSADGLTDAAR

Nucleotide

• Length: 231 bp

>AT108640 NZ_CP031229:2896027-2896257 [Ornithinimicrobium sp. AMA3305]
ATGAAGGTGAGTGTGAGTCTGAGCGAGCAAGACCTCGCGGCCCTCGACCGTTACGTGGAAGAAGCTGGCCTCGAGTCGAG
GTCCGCTGCCGTCCAGCAGGCCATCCGCCGTCTGCAAGACCCGCAGCTGGAGGCGGCCTATGCCGCCGCCTGGGAGGAGT
GGGCCGTCGCAGGGGACGAAGACGCGTGGGCGTCAACGTCCGCGGACGGGCTGACCGATGCTGCGCGGTGA