Detailed information of TA system TA108639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2889723..2890287
• Replicon: chromosome
• Accession: NZ_CP031229
• Organism: Ornithinimicrobium sp. AMA3305

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DV701_RS13120
• Protein ID: WP_114928873.1
• Coordinates: 2889940..2890287 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: DV701_RS13115
• Protein ID: WP_114928871.1
• Coordinates: 2889723..2889953 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV701_RS13095	2885185..2886651	+	1467	WP_114928863.1	OmpA family protein	-
DV701_RS13100	2886726..2887055	+	330	WP_114928865.1	rhodanese-like domain-containing protein	-
DV701_RS13105	2887087..2887923	-	837	WP_162803025.1	HAD hydrolase-like protein	-
DV701_RS13110	2888113..2889321	+	1209	WP_114928869.1	ATP-binding protein	-
DV701_RS13115	2889723..2889953	+	231	WP_114928871.1	ribbon-helix-helix domain-containing protein	Antitoxin
DV701_RS13120	2889940..2890287	+	348	WP_114928873.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DV701_RS13125	2890330..2890650	-	321	WP_202863531.1	DUF86 domain-containing protein	-
DV701_RS13130	2890647..2890967	-	321	WP_114928875.1	nucleotidyltransferase family protein	-
DV701_RS13135	2891063..2891503	-	441	WP_162803026.1	hypothetical protein	-
DV701_RS13140	2891695..2891997	+	303	WP_114928877.1	hypothetical protein	-
DV701_RS13145	2892040..2892324	-	285	WP_022920210.1	hypothetical protein	-
DV701_RS13150	2892477..2892785	+	309	WP_022920209.1	LysR family transcriptional regulator substrate-binding protein	-
DV701_RS13155	2892997..2893602	-	606	WP_084617068.1	Lrp/AsnC family transcriptional regulator	-
DV701_RS13160	2893601..2894632	+	1032	WP_114928878.1	pyridoxal-phosphate dependent enzyme	-
DV701_RS13165	2894930..2895202	+	273	WP_114928879.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12502.50 Da
• Isoelectric Point: 11.1582

>T108639 WP_114928873.1 NZ_CP031229:2889940-2890287 [Ornithinimicrobium sp. AMA3305]
MLRGEILLVDLDPVRGSEANKRRPAVLVSNERANTMGQRLGRGVVSVVPVTSNVERVFPFQVLLPADETGLRVDSKAQAE
QVRSVAVERVGSAVGRVPPRLMAAVDEALRLHLQL

Nucleotide

• Length: 348 bp

>T108639 NZ_CP031229:2889940-2890287 [Ornithinimicrobium sp. AMA3305]
ATGCTGCGCGGTGAGATCCTTCTCGTCGATCTGGATCCAGTGCGCGGGAGCGAGGCCAACAAGCGGCGCCCCGCGGTGCT
CGTCAGCAATGAGCGGGCGAACACCATGGGTCAACGACTCGGTCGTGGAGTAGTCAGCGTCGTGCCCGTCACCAGCAACG
TGGAGCGGGTCTTCCCGTTCCAGGTGTTGCTGCCAGCTGACGAGACAGGACTGCGGGTGGACTCCAAGGCCCAGGCGGAG
CAGGTGCGCTCGGTCGCAGTCGAGCGGGTCGGTTCTGCGGTAGGCCGGGTGCCGCCCCGCCTCATGGCTGCGGTCGACGA
GGCGTTGCGACTCCATCTGCAGCTATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8241.92 Da
• Isoelectric Point: 3.7834

>AT108639 WP_114928871.1 NZ_CP031229:2889723-2889953 [Ornithinimicrobium sp. AMA3305]
MKVSVSLSEEDLAALDRYVEEAGLESRSAAVQQAIRRLQDPQLEAAYADAWEEWAVAGDEDVWASASSDGLTDAAR

Nucleotide

• Length: 231 bp

>AT108639 NZ_CP031229:2889723-2889953 [Ornithinimicrobium sp. AMA3305]
ATGAAGGTGAGCGTGAGTCTGAGCGAGGAGGATCTCGCGGCCCTCGACCGGTACGTCGAAGAAGCTGGCCTGGAGTCGAG
GTCCGCTGCCGTCCAGCAGGCCATCCGCCGCCTGCAGGACCCGCAGCTGGAGGCGGCCTATGCCGACGCCTGGGAGGAGT
GGGCCGTCGCGGGGGACGAGGACGTGTGGGCATCAGCGTCCTCGGACGGGCTTACCGATGCTGCGCGGTGA