Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2452789..2453345 Replicon chromosome
Accession NZ_CP031229
Organism Ornithinimicrobium sp. AMA3305

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DV701_RS11220 Protein ID WP_114928380.1
Coordinates 2453025..2453345 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DV701_RS11215 Protein ID WP_114928379.1
Coordinates 2452789..2453022 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV701_RS11190 2449498..2450292 + 795 Protein_2194 PaaX family transcriptional regulator -
DV701_RS11195 2450396..2451499 - 1104 WP_114928377.1 YihY/virulence factor BrkB family protein -
DV701_RS11200 2451647..2452153 - 507 WP_202863508.1 site-specific integrase -
DV701_RS11205 2452233..2452469 + 237 WP_114928378.1 BrnT family toxin -
DV701_RS11210 2452483..2452725 + 243 WP_114931042.1 hypothetical protein -
DV701_RS11215 2452789..2453022 + 234 WP_114928379.1 ribbon-helix-helix domain-containing protein Antitoxin
DV701_RS11220 2453025..2453345 + 321 WP_114928380.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DV701_RS11225 2453573..2454277 - 705 WP_162802982.1 hypothetical protein -
DV701_RS11230 2454515..2454880 + 366 WP_162802983.1 hypothetical protein -
DV701_RS11235 2456008..2457069 - 1062 WP_162803128.1 IS630 family transposase -
DV701_RS11240 2457356..2458279 - 924 WP_114928384.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2456008..2456979 971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11610.55 Da        Isoelectric Point: 7.1669

>T108638 WP_114928380.1 NZ_CP031229:2453025-2453345 [Ornithinimicrobium sp. AMA3305]
MREICLARLDKTRPVLVLTRDTARAVMTKVTVAPITSTIKRLSSEVPVGRANGLDHNGAVSIDNVLTIPTDLLGRTLGFL
TPEQERHLARAIVLAYDLEVPLLDEP

Download         Length: 321 bp

>T108638 NZ_CP031229:2453025-2453345 [Ornithinimicrobium sp. AMA3305]
TTGCGCGAGATCTGCCTGGCGCGGCTGGATAAGACCCGCCCAGTCCTGGTGCTCACCCGCGACACTGCCCGAGCCGTGAT
GACCAAGGTGACCGTGGCTCCCATCACGTCGACCATCAAGAGGTTGTCCAGCGAAGTGCCGGTAGGACGTGCCAACGGGC
TGGACCACAACGGTGCTGTCTCGATCGACAACGTCCTTACCATCCCCACCGACCTCCTGGGCCGGACGCTGGGCTTCCTC
ACGCCCGAGCAGGAGCGCCACCTTGCACGAGCCATCGTGCTGGCGTACGACCTCGAGGTGCCGTTGCTGGATGAGCCGTG
A

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8408.57 Da        Isoelectric Point: 5.0176

>AT108638 WP_114928379.1 NZ_CP031229:2452789-2453022 [Ornithinimicrobium sp. AMA3305]
MTTQIAIRLPDEMVRFLDRSVASGKAPSRAALVAAALEREMRLQAAQQDAQTLKKKGTADDLDELVTWSVAHATLDD

Download         Length: 234 bp

>AT108638 NZ_CP031229:2452789-2453022 [Ornithinimicrobium sp. AMA3305]
ATGACGACACAGATCGCGATACGGCTCCCTGATGAGATGGTTCGCTTTCTGGACCGGAGCGTGGCCAGTGGCAAGGCTCC
CAGTCGAGCCGCGCTGGTGGCCGCAGCCCTAGAGCGCGAGATGCGCCTGCAAGCCGCGCAGCAGGACGCCCAGACCCTGA
AGAAGAAGGGCACGGCCGATGACCTCGACGAGCTCGTCACCTGGTCCGTAGCCCACGCGACACTGGACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References