Detailed information of TA system TA108637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-YefM
• Location: 1922223..1922761
• Replicon: chromosome
• Accession: NZ_CP031229
• Organism: Ornithinimicrobium sp. AMA3305

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DV701_RS08765
• Protein ID: WP_114927975.1
• Coordinates: 1922486..1922761 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DV701_RS08760
• Protein ID: WP_114927974.1
• Coordinates: 1922223..1922489 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV701_RS08720	1917452..1918027	-	576	WP_114927969.1	YggS family pyridoxal phosphate-dependent enzyme	-
DV701_RS08730	1918387..1919535	+	1149	WP_162802924.1	ATP-binding protein	-
DV701_RS08735	1919508..1919723	-	216	WP_114927971.1	toxin	-
DV701_RS08740	1919720..1919968	-	249	WP_114927972.1	ribbon-helix-helix protein, CopG family	-
DV701_RS18415	1920300..1920788	+	489	WP_202863672.1	transposase	-
DV701_RS18420	1920795..1921052	+	258	WP_202863715.1	transposase	-
DV701_RS08755	1921289..1921906	+	618	WP_162802925.1	hypothetical protein	-
DV701_RS08760	1922223..1922489	+	267	WP_114927974.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DV701_RS08765	1922486..1922761	+	276	WP_114927975.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV701_RS08770	1923036..1923524	-	489	WP_114927976.1	hypothetical protein	-
DV701_RS18425	1923775..1924143	+	369	WP_202863673.1	hypothetical protein	-
DV701_RS08780	1924313..1924845	+	533	Protein_1723	response regulator transcription factor	-
DV701_RS08785	1924966..1926327	+	1362	WP_114930941.1	cystathionine beta-synthase	-
DV701_RS08790	1926342..1927487	+	1146	WP_114927977.1	cystathionine gamma-synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (34-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10246.86 Da
• Isoelectric Point: 11.5026

>T108637 WP_114927975.1 NZ_CP031229:1922486-1922761 [Ornithinimicrobium sp. AMA3305]
VTLPFELVLTPPATRAIQRGLPESVAAAVVEFFTGALIDNPQRVGKPLRGELAGIRSARRGTYRVLYRINEQAREVVVLR
VEHRRDVYGRH

Nucleotide

• Length: 276 bp

>T108637 NZ_CP031229:1922486-1922761 [Ornithinimicrobium sp. AMA3305]
GTGACGCTCCCTTTCGAGCTTGTCCTGACCCCCCCGGCTACCCGGGCGATCCAGCGGGGTCTACCCGAGTCCGTGGCTGC
GGCAGTCGTCGAGTTTTTCACCGGGGCCCTCATCGACAACCCCCAGCGAGTGGGCAAGCCCCTTCGCGGCGAGCTCGCCG
GCATCCGTTCCGCACGCCGGGGGACCTATCGAGTCCTCTACCGGATCAACGAGCAGGCTCGCGAAGTCGTCGTGCTGCGC
GTCGAGCACCGTCGCGACGTATACGGTCGCCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9651.79 Da
• Isoelectric Point: 4.2591

>AT108637 WP_114927974.1 NZ_CP031229:1922223-1922489 [Ornithinimicrobium sp. AMA3305]
MSIESLREVRDHFSDVVDRVQREHERVTVTRNGKAAAVILSPEDLAELEETLAVLSDPEALADIREADLAYQAGDVVRGA
DAVRALLP

Nucleotide

• Length: 267 bp

>AT108637 NZ_CP031229:1922223-1922489 [Ornithinimicrobium sp. AMA3305]
ATGAGCATCGAGTCCCTGCGCGAGGTCCGCGATCACTTCAGCGACGTTGTCGACCGAGTGCAGCGCGAGCACGAGCGGGT
CACGGTGACGCGCAACGGCAAGGCAGCAGCGGTCATCCTCAGCCCGGAAGACCTGGCCGAGCTCGAAGAGACCCTGGCCG
TCCTCAGTGACCCTGAGGCGCTGGCCGACATCCGCGAAGCCGACCTCGCATACCAGGCAGGAGACGTGGTCCGCGGAGCA
GATGCGGTCCGGGCATTGCTCCCGTGA