Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 303957..304555 Replicon chromosome
Accession NZ_CP031229
Organism Ornithinimicrobium sp. AMA3305

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag DV701_RS01415 Protein ID WP_114926773.1
Coordinates 303957..304262 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag DV701_RS01420 Protein ID WP_114926774.1
Coordinates 304259..304555 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV701_RS01385 299987..301936 + 1950 WP_114926769.1 DNA primase -
DV701_RS01390 301936..302520 + 585 WP_114926770.1 hypothetical protein -
DV701_RS01400 302851..303057 - 207 WP_114926771.1 helix-turn-helix domain-containing protein -
DV701_RS01405 303311..303514 + 204 WP_075958334.1 toxin-antitoxin system HicB family antitoxin -
DV701_RS01410 303511..303876 + 366 WP_114926772.1 Fic family protein -
DV701_RS01415 303957..304262 + 306 WP_114926773.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DV701_RS01420 304259..304555 + 297 WP_114926774.1 putative addiction module antidote protein Antitoxin
DV701_RS01425 304668..305081 - 414 WP_114926775.1 hypothetical protein -
DV701_RS01430 306037..307299 + 1263 WP_202863595.1 group II intron reverse transcriptase/maturase -
DV701_RS01435 307490..308776 + 1287 WP_114926776.1 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 302668..323013 20345
- flank IS/Tn - - 307490..308776 1286


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-88)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-92)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11418.08 Da        Isoelectric Point: 10.6925

>T108636 WP_114926773.1 NZ_CP031229:303957-304262 [Ornithinimicrobium sp. AMA3305]
MVQVVRSATFDRWLGKLKDQRAAARVLVRINRLAAGNPGDVKPVGQGVSEMRINYGPGYRIYYLTHDDRVVLLLTGGDKS
TQETDIRKAHDIAAEWKRNRP

Download         Length: 306 bp

>T108636 NZ_CP031229:303957-304262 [Ornithinimicrobium sp. AMA3305]
ATGGTGCAGGTCGTCCGATCCGCAACGTTCGATCGATGGCTGGGCAAGCTGAAGGACCAACGTGCGGCCGCGCGCGTGCT
GGTCCGGATCAACCGGCTCGCGGCGGGTAACCCCGGCGACGTCAAGCCTGTCGGGCAGGGCGTCAGCGAGATGCGAATCA
ACTACGGCCCGGGATATCGCATCTACTACCTGACCCACGACGACCGGGTCGTCCTGCTGCTGACCGGTGGCGACAAGTCG
ACCCAGGAAACAGACATCCGCAAGGCCCACGACATCGCCGCCGAATGGAAAAGGAACCGACCATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10510.84 Da        Isoelectric Point: 4.3431

>AT108636 WP_114926774.1 NZ_CP031229:304259-304555 [Ornithinimicrobium sp. AMA3305]
MTNETFAPFDSADYLNTFEDVAAYLEAVLEEAEDDPKVIAAALGAIARSRNLSEIARQAGMSREGLYKALSADGNPSLAT
VVKVAHVLGLRLHFETIA

Download         Length: 297 bp

>AT108636 NZ_CP031229:304259-304555 [Ornithinimicrobium sp. AMA3305]
ATGACCAACGAGACATTCGCCCCCTTCGACAGCGCGGACTACCTCAACACCTTCGAGGACGTGGCCGCCTACCTGGAAGC
GGTCCTGGAAGAAGCCGAGGATGACCCGAAGGTCATCGCTGCCGCGCTCGGAGCCATCGCTCGCTCTCGCAACCTGAGCG
AGATCGCCCGACAGGCCGGGATGAGCCGAGAAGGCCTGTACAAGGCACTCTCCGCGGACGGAAACCCCTCATTGGCAACC
GTGGTCAAGGTTGCCCATGTCCTTGGCCTACGGTTGCACTTCGAAACTATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References