Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 303957..304555 | Replicon | chromosome |
| Accession | NZ_CP031229 | ||
| Organism | Ornithinimicrobium sp. AMA3305 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | - |
| Locus tag | DV701_RS01415 | Protein ID | WP_114926773.1 |
| Coordinates | 303957..304262 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | DV701_RS01420 | Protein ID | WP_114926774.1 |
| Coordinates | 304259..304555 (+) | Length | 99 a.a. |
Genomic Context
Location: 299987..301936 (1950 bp)
Type: Others
Protein ID: WP_114926769.1
Type: Others
Protein ID: WP_114926769.1
Location: 301936..302520 (585 bp)
Type: Others
Protein ID: WP_114926770.1
Type: Others
Protein ID: WP_114926770.1
Location: 303311..303514 (204 bp)
Type: Others
Protein ID: WP_075958334.1
Type: Others
Protein ID: WP_075958334.1
Location: 303511..303876 (366 bp)
Type: Others
Protein ID: WP_114926772.1
Type: Others
Protein ID: WP_114926772.1
Location: 303957..304262 (306 bp)
Type: Toxin
Protein ID: WP_114926773.1
Type: Toxin
Protein ID: WP_114926773.1
Location: 304259..304555 (297 bp)
Type: Antitoxin
Protein ID: WP_114926774.1
Type: Antitoxin
Protein ID: WP_114926774.1
Location: 306037..307299 (1263 bp)
Type: Others
Protein ID: WP_202863595.1
Type: Others
Protein ID: WP_202863595.1
Location: 307490..308776 (1287 bp)
Type: Others
Protein ID: WP_114926776.1
Type: Others
Protein ID: WP_114926776.1
Location: 302851..303057 (207 bp)
Type: Others
Protein ID: WP_114926771.1
Type: Others
Protein ID: WP_114926771.1
Location: 304668..305081 (414 bp)
Type: Others
Protein ID: WP_114926775.1
Type: Others
Protein ID: WP_114926775.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DV701_RS01385 | 299987..301936 | + | 1950 | WP_114926769.1 | DNA primase | - |
| DV701_RS01390 | 301936..302520 | + | 585 | WP_114926770.1 | hypothetical protein | - |
| DV701_RS01400 | 302851..303057 | - | 207 | WP_114926771.1 | helix-turn-helix domain-containing protein | - |
| DV701_RS01405 | 303311..303514 | + | 204 | WP_075958334.1 | toxin-antitoxin system HicB family antitoxin | - |
| DV701_RS01410 | 303511..303876 | + | 366 | WP_114926772.1 | Fic family protein | - |
| DV701_RS01415 | 303957..304262 | + | 306 | WP_114926773.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DV701_RS01420 | 304259..304555 | + | 297 | WP_114926774.1 | putative addiction module antidote protein | Antitoxin |
| DV701_RS01425 | 304668..305081 | - | 414 | WP_114926775.1 | hypothetical protein | - |
| DV701_RS01430 | 306037..307299 | + | 1263 | WP_202863595.1 | group II intron reverse transcriptase/maturase | - |
| DV701_RS01435 | 307490..308776 | + | 1287 | WP_114926776.1 | IS256 family transposase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 302668..323013 | 20345 | |
| - | flank | IS/Tn | - | - | 307490..308776 | 1286 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11418.08 Da Isoelectric Point: 10.6925
>T108636 WP_114926773.1 NZ_CP031229:303957-304262 [Ornithinimicrobium sp. AMA3305]
MVQVVRSATFDRWLGKLKDQRAAARVLVRINRLAAGNPGDVKPVGQGVSEMRINYGPGYRIYYLTHDDRVVLLLTGGDKS
TQETDIRKAHDIAAEWKRNRP
MVQVVRSATFDRWLGKLKDQRAAARVLVRINRLAAGNPGDVKPVGQGVSEMRINYGPGYRIYYLTHDDRVVLLLTGGDKS
TQETDIRKAHDIAAEWKRNRP
Download Length: 306 bp
>T108636 NZ_CP031229:303957-304262 [Ornithinimicrobium sp. AMA3305]
ATGGTGCAGGTCGTCCGATCCGCAACGTTCGATCGATGGCTGGGCAAGCTGAAGGACCAACGTGCGGCCGCGCGCGTGCT
GGTCCGGATCAACCGGCTCGCGGCGGGTAACCCCGGCGACGTCAAGCCTGTCGGGCAGGGCGTCAGCGAGATGCGAATCA
ACTACGGCCCGGGATATCGCATCTACTACCTGACCCACGACGACCGGGTCGTCCTGCTGCTGACCGGTGGCGACAAGTCG
ACCCAGGAAACAGACATCCGCAAGGCCCACGACATCGCCGCCGAATGGAAAAGGAACCGACCATGA
ATGGTGCAGGTCGTCCGATCCGCAACGTTCGATCGATGGCTGGGCAAGCTGAAGGACCAACGTGCGGCCGCGCGCGTGCT
GGTCCGGATCAACCGGCTCGCGGCGGGTAACCCCGGCGACGTCAAGCCTGTCGGGCAGGGCGTCAGCGAGATGCGAATCA
ACTACGGCCCGGGATATCGCATCTACTACCTGACCCACGACGACCGGGTCGTCCTGCTGCTGACCGGTGGCGACAAGTCG
ACCCAGGAAACAGACATCCGCAAGGCCCACGACATCGCCGCCGAATGGAAAAGGAACCGACCATGA
Antitoxin
Download Length: 99 a.a. Molecular weight: 10510.84 Da Isoelectric Point: 4.3431
>AT108636 WP_114926774.1 NZ_CP031229:304259-304555 [Ornithinimicrobium sp. AMA3305]
MTNETFAPFDSADYLNTFEDVAAYLEAVLEEAEDDPKVIAAALGAIARSRNLSEIARQAGMSREGLYKALSADGNPSLAT
VVKVAHVLGLRLHFETIA
MTNETFAPFDSADYLNTFEDVAAYLEAVLEEAEDDPKVIAAALGAIARSRNLSEIARQAGMSREGLYKALSADGNPSLAT
VVKVAHVLGLRLHFETIA
Download Length: 297 bp
>AT108636 NZ_CP031229:304259-304555 [Ornithinimicrobium sp. AMA3305]
ATGACCAACGAGACATTCGCCCCCTTCGACAGCGCGGACTACCTCAACACCTTCGAGGACGTGGCCGCCTACCTGGAAGC
GGTCCTGGAAGAAGCCGAGGATGACCCGAAGGTCATCGCTGCCGCGCTCGGAGCCATCGCTCGCTCTCGCAACCTGAGCG
AGATCGCCCGACAGGCCGGGATGAGCCGAGAAGGCCTGTACAAGGCACTCTCCGCGGACGGAAACCCCTCATTGGCAACC
GTGGTCAAGGTTGCCCATGTCCTTGGCCTACGGTTGCACTTCGAAACTATCGCCTGA
ATGACCAACGAGACATTCGCCCCCTTCGACAGCGCGGACTACCTCAACACCTTCGAGGACGTGGCCGCCTACCTGGAAGC
GGTCCTGGAAGAAGCCGAGGATGACCCGAAGGTCATCGCTGCCGCGCTCGGAGCCATCGCTCGCTCTCGCAACCTGAGCG
AGATCGCCCGACAGGCCGGGATGAGCCGAGAAGGCCTGTACAAGGCACTCTCCGCGGACGGAAACCCCTCATTGGCAACC
GTGGTCAAGGTTGCCCATGTCCTTGGCCTACGGTTGCACTTCGAAACTATCGCCTGA