Detailed information of TA system TA108636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 303957..304555
• Replicon: chromosome
• Accession: NZ_CP031229
• Organism: Ornithinimicrobium sp. AMA3305

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: DV701_RS01415
• Protein ID: WP_114926773.1
• Coordinates: 303957..304262 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DV701_RS01420
• Protein ID: WP_114926774.1
• Coordinates: 304259..304555 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DV701_RS01385	299987..301936	+	1950	WP_114926769.1	DNA primase	-
DV701_RS01390	301936..302520	+	585	WP_114926770.1	hypothetical protein	-
DV701_RS01400	302851..303057	-	207	WP_114926771.1	helix-turn-helix domain-containing protein	-
DV701_RS01405	303311..303514	+	204	WP_075958334.1	toxin-antitoxin system HicB family antitoxin	-
DV701_RS01410	303511..303876	+	366	WP_114926772.1	Fic family protein	-
DV701_RS01415	303957..304262	+	306	WP_114926773.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DV701_RS01420	304259..304555	+	297	WP_114926774.1	putative addiction module antidote protein	Antitoxin
DV701_RS01425	304668..305081	-	414	WP_114926775.1	hypothetical protein	-
DV701_RS01430	306037..307299	+	1263	WP_202863595.1	group II intron reverse transcriptase/maturase	-
DV701_RS01435	307490..308776	+	1287	WP_114926776.1	IS256 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	302668..323013	20345
	-	flank	IS/Tn	-	-	307490..308776	1286

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-88)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-92)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11418.08 Da
• Isoelectric Point: 10.6925

>T108636 WP_114926773.1 NZ_CP031229:303957-304262 [Ornithinimicrobium sp. AMA3305]
MVQVVRSATFDRWLGKLKDQRAAARVLVRINRLAAGNPGDVKPVGQGVSEMRINYGPGYRIYYLTHDDRVVLLLTGGDKS
TQETDIRKAHDIAAEWKRNRP

Nucleotide

• Length: 306 bp

>T108636 NZ_CP031229:303957-304262 [Ornithinimicrobium sp. AMA3305]
ATGGTGCAGGTCGTCCGATCCGCAACGTTCGATCGATGGCTGGGCAAGCTGAAGGACCAACGTGCGGCCGCGCGCGTGCT
GGTCCGGATCAACCGGCTCGCGGCGGGTAACCCCGGCGACGTCAAGCCTGTCGGGCAGGGCGTCAGCGAGATGCGAATCA
ACTACGGCCCGGGATATCGCATCTACTACCTGACCCACGACGACCGGGTCGTCCTGCTGCTGACCGGTGGCGACAAGTCG
ACCCAGGAAACAGACATCCGCAAGGCCCACGACATCGCCGCCGAATGGAAAAGGAACCGACCATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10510.84 Da
• Isoelectric Point: 4.3431

>AT108636 WP_114926774.1 NZ_CP031229:304259-304555 [Ornithinimicrobium sp. AMA3305]
MTNETFAPFDSADYLNTFEDVAAYLEAVLEEAEDDPKVIAAALGAIARSRNLSEIARQAGMSREGLYKALSADGNPSLAT
VVKVAHVLGLRLHFETIA

Nucleotide

• Length: 297 bp

>AT108636 NZ_CP031229:304259-304555 [Ornithinimicrobium sp. AMA3305]
ATGACCAACGAGACATTCGCCCCCTTCGACAGCGCGGACTACCTCAACACCTTCGAGGACGTGGCCGCCTACCTGGAAGC
GGTCCTGGAAGAAGCCGAGGATGACCCGAAGGTCATCGCTGCCGCGCTCGGAGCCATCGCTCGCTCTCGCAACCTGAGCG
AGATCGCCCGACAGGCCGGGATGAGCCGAGAAGGCCTGTACAAGGCACTCTCCGCGGACGGAAACCCCTCATTGGCAACC
GTGGTCAAGGTTGCCCATGTCCTTGGCCTACGGTTGCACTTCGAAACTATCGCCTGA