Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 198721..199360 Replicon chromosome
Accession NZ_CP031225
Organism Pseudomonas amygdali pv. lachrymans str. M301315

Toxin (Protein)


Gene name hicA Uniprot ID A0A3M5IA75
Locus tag PLA107_RS00955 Protein ID WP_005745047.1
Coordinates 199178..199360 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0Q0DRU8
Locus tag PLA107_RS00950 Protein ID WP_016981256.1
Coordinates 198721..199146 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PLA107_RS00935 195181..196503 + 1323 WP_029240926.1 murein hydrolase activator EnvC -
PLA107_RS00940 196537..197880 + 1344 WP_005745050.1 S41 family peptidase -
PLA107_RS00945 197884..198666 + 783 WP_005745049.1 divergent polysaccharide deacetylase family protein -
PLA107_RS00950 198721..199146 - 426 WP_016981256.1 transcriptional regulator Antitoxin
PLA107_RS00955 199178..199360 - 183 WP_005745047.1 type II toxin-antitoxin system HicA family toxin Toxin
PLA107_RS00960 199682..199922 + 241 Protein_177 serine protease -
PLA107_RS00965 199927..200682 - 756 WP_004663214.1 ABC transporter substrate-binding protein -
PLA107_RS00970 200868..201638 - 771 WP_002551458.1 imidazole glycerol phosphate synthase subunit HisF -
PLA107_RS00975 201658..202395 - 738 WP_002551457.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
PLA107_RS00980 202503..202763 - 261 WP_002551456.1 DUF2164 domain-containing protein -
PLA107_RS00985 202768..203406 - 639 WP_005745046.1 imidazole glycerol phosphate synthase subunit HisH -
PLA107_RS00990 203406..203999 - 594 WP_002551454.1 imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6892.00 Da        Isoelectric Point: 10.6211

>T108629 WP_005745047.1 NZ_CP031225:c199360-199178 [Pseudomonas amygdali pv. lachrymans str. M301315]
MKCNEFRRWLQAQGAEFRAAKGSHFKIYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T108629 NZ_CP031225:c199360-199178 [Pseudomonas amygdali pv. lachrymans str. M301315]
ATGAAGTGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCTGCCAAGGGTAGTCATTTCAAGAT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGAAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15783.24 Da        Isoelectric Point: 5.2548

>AT108629 WP_016981256.1 NZ_CP031225:c199146-198721 [Pseudomonas amygdali pv. lachrymans str. M301315]
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEAFSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERAA

Download         Length: 426 bp

>AT108629 NZ_CP031225:c199146-198721 [Pseudomonas amygdali pv. lachrymans str. M301315]
ATGTATCAATATCCATTGGATCTACATCGGGAGCCGACAGGCGTTTGGCTGTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTTAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAGC
GTCGCAAGATTCCCCAAGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACGGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTCGGTTGCACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGTCGGCGTATTA
CGTTGAGCATTGAGCGGGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M5IA75

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0DRU8

References