Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1600041..1600594 Replicon chromosome
Accession NZ_CP031222
Organism Aquirhabdus parva strain HYN0046

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HYN46_RS07155 Protein ID WP_114898733.1
Coordinates 1600244..1600594 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HYN46_RS07150 Protein ID WP_228254917.1
Coordinates 1600041..1600247 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYN46_RS07140 (HYN46_07140) 1596866..1598896 + 2031 WP_114900669.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
HYN46_RS07145 (HYN46_07145) 1598995..1599507 - 513 WP_114898731.1 OsmC family protein -
HYN46_RS07150 (HYN46_07150) 1600041..1600247 + 207 WP_228254917.1 antitoxin MazE family protein Antitoxin
HYN46_RS07155 (HYN46_07155) 1600244..1600594 + 351 WP_114898733.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HYN46_RS07160 (HYN46_07160) 1600665..1601405 - 741 WP_114898734.1 phosphoadenylyl-sulfate reductase -
HYN46_RS07165 (HYN46_07165) 1601680..1602297 + 618 WP_114898735.1 bifunctional phosphoserine phosphatase/homoserine phosphotransferase ThrH -
HYN46_RS07170 (HYN46_07170) 1602613..1602954 + 342 WP_162818108.1 YXWGXW repeat-containing protein -
HYN46_RS07175 (HYN46_07175) 1603039..1604745 - 1707 WP_114898737.1 FMN-binding glutamate synthase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-112)

Antitoxin

Antitoxin MazE-like

(4-67)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12834.86 Da        Isoelectric Point: 4.8182

>T108627 WP_114898733.1 NZ_CP031222:1600244-1600594 [Aquirhabdus parva]
MTSELVESTFKRGDIVTVAVQGDYRVRRPALVIQSNLFSVHPSIVILPITDERLEAPLFRVHVEPSELNGLLQASQVMVD
KPQTLSRDKIGEVVGQLDPDILQAVDRALIVFLGFA

Download         Length: 351 bp

>T108627 NZ_CP031222:1600244-1600594 [Aquirhabdus parva]
TTGACCAGTGAACTAGTCGAATCGACTTTTAAGCGTGGTGATATCGTCACCGTAGCAGTACAAGGGGATTACCGAGTACG
TCGCCCAGCGCTTGTCATACAGTCGAATTTGTTTTCTGTACACCCTTCAATCGTCATCTTACCGATTACTGACGAGCGAC
TTGAGGCTCCTTTGTTTCGCGTTCATGTTGAGCCGAGTGAGTTAAATGGCTTACTCCAAGCTTCGCAAGTTATGGTAGAT
AAGCCACAGACCCTTTCTCGAGATAAGATTGGAGAGGTTGTAGGGCAGTTGGATCCTGATATTCTACAAGCGGTCGATCG
CGCGTTGATCGTTTTCTTAGGATTTGCTTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7747.72 Da        Isoelectric Point: 7.1670

>AT108627 WP_228254917.1 NZ_CP031222:1600041-1600247 [Aquirhabdus parva]
MSVAERVQKHREALRASGLRPVQIWVADTRQKGFAEECRRQSLSIQGAALEREVAGWLDVFGDQEGWH

Download         Length: 207 bp

>AT108627 NZ_CP031222:1600041-1600247 [Aquirhabdus parva]
ATGAGTGTTGCTGAAAGAGTGCAAAAACATCGGGAGGCTCTGCGTGCATCAGGGCTACGCCCCGTACAGATATGGGTGGC
AGATACTCGGCAGAAAGGTTTTGCTGAGGAGTGTCGTCGTCAATCGCTGTCTATTCAGGGTGCCGCGCTTGAACGCGAGG
TTGCAGGCTGGCTAGATGTGTTTGGTGATCAGGAGGGCTGGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References