Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 944475..945049 Replicon chromosome
Accession NZ_CP031217
Organism Halarcobacter bivalviorum strain LMG 26154

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ABIV_RS04745 Protein ID WP_114838810.1
Coordinates 944475..944810 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ABIV_RS04750 Protein ID WP_114838811.1
Coordinates 944804..945049 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABIV_RS04725 939918..940268 + 351 WP_114838807.1 50S ribosomal protein L17 -
ABIV_RS04730 940442..941803 + 1362 WP_162917974.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
ABIV_RS04735 941826..943271 + 1446 WP_114838808.1 IMP dehydrogenase -
ABIV_RS04740 943462..944298 + 837 WP_114838809.1 hypothetical protein -
ABIV_RS04745 944475..944810 - 336 WP_114838810.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ABIV_RS04750 944804..945049 - 246 WP_114838811.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ABIV_RS04755 945178..945525 + 348 WP_114838812.1 rhodanese-like domain-containing protein -
ABIV_RS04760 945544..946047 - 504 WP_114838813.1 hypothetical protein -
ABIV_RS04765 946212..946418 + 207 WP_114838814.1 hypothetical protein -
ABIV_RS04770 946532..946861 + 330 WP_114838815.1 hypothetical protein -
ABIV_RS04775 946927..947157 + 231 WP_114838816.1 DUF350 domain-containing protein -
ABIV_RS04780 947202..947978 + 777 WP_205526955.1 transglutaminase domain-containing protein -
ABIV_RS04785 948145..949143 + 999 WP_114838818.1 HEAT repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-103)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12504.58 Da        Isoelectric Point: 9.6558

>T108626 WP_114838810.1 NZ_CP031217:c944810-944475 [Halarcobacter bivalviorum]
MVKNYIPKKGDLVILTFDPQAGHEQKGRRPALIISNEAFNKALGLAIACPITNTNRDFPFHVKLESENLTGFIMTEQIKS
IDFNARKVKFVEKVDEETLNKVLGITKSVIF

Download         Length: 336 bp

>T108626 NZ_CP031217:c944810-944475 [Halarcobacter bivalviorum]
ATGGTAAAAAATTATATTCCTAAAAAAGGAGATTTAGTAATACTTACTTTTGACCCACAAGCTGGACACGAACAAAAAGG
AAGAAGACCAGCACTAATTATTAGTAATGAAGCTTTTAATAAAGCATTAGGATTAGCAATAGCTTGCCCAATCACTAATA
CAAATAGAGACTTCCCTTTTCATGTAAAACTTGAAAGTGAAAATCTAACAGGCTTTATAATGACTGAACAGATTAAATCT
ATTGATTTTAATGCTAGAAAAGTAAAGTTTGTAGAAAAAGTAGATGAAGAGACTTTAAATAAAGTTCTTGGAATTACTAA
AAGTGTGATTTTTTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9200.36 Da        Isoelectric Point: 4.2457

>AT108626 WP_114838811.1 NZ_CP031217:c945049-944804 [Halarcobacter bivalviorum]
MTAKISKWGNSQGLRVPKDIMESLQLHIGDNVNITIVDGKAIIEPVRQDIPDYDLNELVSKVPEDYKANEEFDTTIGKEE
W

Download         Length: 246 bp

>AT108626 NZ_CP031217:c945049-944804 [Halarcobacter bivalviorum]
ATGACTGCTAAAATTTCAAAATGGGGTAACTCTCAAGGGCTTAGAGTACCAAAAGATATAATGGAAAGTTTACAACTTCA
TATTGGCGATAATGTAAATATTACAATAGTAGATGGTAAAGCAATTATTGAGCCAGTAAGACAAGATATTCCTGACTATG
ATTTAAATGAACTAGTATCTAAAGTACCAGAAGACTATAAAGCAAATGAAGAGTTTGATACAACAATAGGAAAAGAGGAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References