Detailed information of TA system TA108592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3991885..3992699
• Replicon: chromosome
• Accession: NZ_CP031214
• Organism: Escherichia coli strain C600

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: DK885_RS20745
• Protein ID: WP_001054376.1
• Coordinates: 3991885..3992142 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: DK885_RS20750
• Protein ID: WP_001309181.1
• Coordinates: 3992154..3992699 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DK885_RS20715	3987173..3988279	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
DK885_RS20720	3988344..3989324	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
DK885_RS20725	3989907..3991147	-	1241	Protein_3789	helicase YjhR	-
DK885_RS20735	3991263..3991508	+	246	Protein_3790	GNAT family N-acetyltransferase	-
DK885_RS20745	3991885..3992142	+	258	WP_001054376.1	hypothetical protein	Toxin
DK885_RS20750	3992154..3992699	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
DK885_RS20755	3992755..3993501	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
DK885_RS20760	3993670..3993888	+	219	Protein_3794	hypothetical protein	-
DK885_RS24165	3993926..3994042	+	117	Protein_3795	VOC family protein	-
DK885_RS20765	3994287..3995408	+	1122	WP_000010829.1	M42 family metallopeptidase	-
DK885_RS20770	3995405..3995683	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DK885_RS20775	3995695..3997008	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	3980896..4000923	20027

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T108592 WP_001054376.1 NZ_CP031214:3991885-3992142 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T108592 NZ_CP031214:3991885-3992142 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT108592 WP_001309181.1 NZ_CP031214:3992154-3992699 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT108592 NZ_CP031214:3992154-3992699 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8