Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1013650..1014456 Replicon chromosome
Accession NZ_CP031196
Organism Staphylococcus saprophyticus strain 1A

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag DV527_RS04990 Protein ID WP_011302805.1
Coordinates 1014271..1014456 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A380HJZ2
Locus tag DV527_RS04985 Protein ID WP_002482876.1
Coordinates 1013650..1014249 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV527_RS04965 1009528..1010991 + 1464 WP_145437484.1 ABC transporter substrate-binding protein/permease -
DV527_RS04970 1010984..1011706 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
DV527_RS04975 1011867..1012994 + 1128 WP_002482874.1 tRNA epoxyqueuosine(34) reductase QueG -
DV527_RS04980 1012999..1013469 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DV527_RS04985 1013650..1014249 + 600 WP_002482876.1 glucosamine-6-phosphate isomerase Antitoxin
DV527_RS04990 1014271..1014456 + 186 WP_011302805.1 hypothetical protein Toxin
DV527_RS04995 1014613..1015029 + 417 WP_011302806.1 hypothetical protein -
DV527_RS05000 1015407..1016792 + 1386 WP_002482879.1 class II fumarate hydratase -
DV527_RS05005 1016995..1017822 - 828 WP_115338456.1 RluA family pseudouridine synthase -
DV527_RS05010 1018007..1019122 + 1116 WP_129530954.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T108563 WP_011302805.1 NZ_CP031196:1014271-1014456 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T108563 NZ_CP031196:1014271-1014456 [Staphylococcus saprophyticus]
ATGAGTTTAGATAAAAATCAAAATAATCTACATCGTGATGAATTAGAGTCAGAAAACGCGATGGTTGATGATTTAGAGGA
TGTCGTAGAATTAGGAAAAGAAATGGAACAAATCTCTGAAGAAAATGATGAAGATAAATTAGATAAATCACATGACCCAG
CAGTACGTTCCGATTTAAATGAATAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22294.12 Da        Isoelectric Point: 4.9719

>AT108563 WP_002482876.1 NZ_CP031196:1013650-1014249 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSSREVILIITGSNKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT108563 NZ_CP031196:1013650-1014249 [Staphylococcus saprophyticus]
ATGGCAATGAACTTTAAAGTTTTAGAAAATGAACAAGTTGTAGCGGAATATGCTGCAGATATCTTAAGAAAACAATTTAA
CAACAATCCAACAACAATTGCTGGTGTACACCTTTCAAGTGACAATGCACCAGTATTGGATGAATTAAAGAAAAATGTTG
ATAAACATGCAGTAGATTTTAGTCAAATTAATATTCTGGATTATGATAACAATAAATCATACTTTGAAGCACTTGGTGTT
CCAGAAGGCCAAATCTTCAATGTTTCATTTGGTGAAGATACGGAATCATTTATTAAAGATAAAATCAAAACTAAAGAAAA
TAAAGGGAAATTGATTACACAAGTACTTTCTATTGATACAAATGGTAAATTAGATGTAAGTGTGAATCAAGGTTTATTCT
CATCACGTGAAGTTATTTTAATTATTACAGGTAGCAATAAAAAAGAAGTCGTTCATAAACTTTATGAAGAAAATGGTAAA
ACAAGTTTTGAACCTTCAGATTTAAAAGCGCATCGTATGGTTAATGTTATTTTAGATGAAGCGGCTGCTGAAGGTTTACC
AGAAGATGTTAGACATTATTTCACTGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJZ2

References