Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 876251..876780 Replicon chromosome
Accession NZ_CP031196
Organism Staphylococcus saprophyticus strain 1A

Toxin (Protein)


Gene name mazF Uniprot ID A0A7Y8QER5
Locus tag DV527_RS04195 Protein ID WP_041080775.1
Coordinates 876418..876780 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A380HJK7
Locus tag DV527_RS04190 Protein ID WP_037538046.1
Coordinates 876251..876421 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV527_RS04165 871982..872461 + 480 WP_002482747.1 PH domain-containing protein -
DV527_RS04170 872454..873992 + 1539 WP_002482748.1 PH domain-containing protein -
DV527_RS04175 873985..874485 + 501 WP_041080777.1 PH domain-containing protein -
DV527_RS04180 874549..874899 + 351 WP_002482750.1 holo-ACP synthase -
DV527_RS04185 875015..876163 + 1149 WP_041080776.1 alanine racemase -
DV527_RS04190 876251..876421 + 171 WP_037538046.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
DV527_RS04195 876418..876780 + 363 WP_041080775.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DV527_RS04200 877117..878118 + 1002 WP_041080774.1 PP2C family protein-serine/threonine phosphatase -
DV527_RS04205 878197..878523 + 327 WP_011302705.1 anti-sigma factor antagonist -
DV527_RS04210 878525..879007 + 483 WP_002482755.1 anti-sigma B factor RsbW -
DV527_RS04215 878982..879752 + 771 WP_041080773.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13511.70 Da        Isoelectric Point: 10.3173

>T108562 WP_041080775.1 NZ_CP031196:876418-876780 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHNIRSHKS

Download         Length: 363 bp

>T108562 NZ_CP031196:876418-876780 [Staphylococcus saprophyticus]
ATGATGAGACGTGGTGACGTTTATTTAGCTGATTTATCACCAGTCCAGGGGTCTGAACAAGGGGGAATAAGACCTGTCGT
AATTATACAAAACGATACTGGTAATAAATATAGTCCTACCGTAATTGTAGCCGCAATTACTGGTAGGATAAATAAAGCTA
AAATACCTACACATGTAGAAATAGAAAAAAGTAAATATAAATTAGATAAAGATTCTGTTATATTGCTAGAGCAGATTAGA
ACTTTAGATAAAAATAGGCTGAAAGAAAAATTAACTTATCTTTCTGATAAAAAAATGAAAGAAGTTAATAATGCCATTGA
TATTAGTTTAGGATTACATAATATTAGGAGTCACAAATCCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6304.97 Da        Isoelectric Point: 4.0121

>AT108562 WP_037538046.1 NZ_CP031196:876251-876421 [Staphylococcus saprophyticus]
MASFNQSRIHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT108562 NZ_CP031196:876251-876421 [Staphylococcus saprophyticus]
ATGGCAAGTTTCAACCAAAGTAGAATTCATAGTATAGAACAACTTTTAAAAGAAGGCTATTCTCAAATGGCTGATTTGAA
CCTCTCCCTCGCAGCAGAAGCATTTCCGTTTGAATGTGAAGCTTGTGATTGCAACGAAGTATATATTAGCTCCAAGAATA
ATAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8QER5

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJK7

References