Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 864585..865099 Replicon chromosome
Accession NZ_CP031196
Organism Staphylococcus saprophyticus strain 1A

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag DV527_RS04135 Protein ID WP_002482741.1
Coordinates 864893..865099 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag DV527_RS04130 Protein ID WP_002482740.1
Coordinates 864585..864878 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DV527_RS04105 859747..860538 + 792 WP_002482735.1 hydroxyethylthiazole kinase -
DV527_RS04110 860538..861176 + 639 WP_002482736.1 thiamine phosphate synthase -
DV527_RS04115 861264..862133 + 870 WP_002482737.1 membrane protein insertase YidC -
DV527_RS04120 862215..862823 - 609 WP_176720937.1 HD domain-containing protein -
DV527_RS04125 862958..864442 - 1485 WP_145437472.1 cardiolipin synthase -
DV527_RS04130 864585..864878 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
DV527_RS04135 864893..865099 + 207 WP_002482741.1 hypothetical protein Toxin
DV527_RS04140 865310..865450 + 141 WP_002482742.1 hypothetical protein -
DV527_RS04145 865754..866947 - 1194 WP_041080781.1 rod shape-determining protein RodA -
DV527_RS04150 867196..868266 + 1071 WP_002482744.1 D-alanine--D-alanine ligase -
DV527_RS04155 868279..869634 + 1356 WP_002482745.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T108561 WP_002482741.1 NZ_CP031196:864893-865099 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T108561 NZ_CP031196:864893-865099 [Staphylococcus saprophyticus]
ATGCAATCAAAAGTTATTTATATTGCTGAACTTTATAATGAGAAGCAAAAATTACAAATTGAAGAAAGACTAATGAAACT
TTATGGTGTGTTTAAAGTTAGTATAGATATAGAAGAAGGCGCAATCTTTGTAGATTTTGAAACGCCTGCAAATTTGAATA
ATTTAGAAAAAGAAGTGTACGATTTAGGTTATAAAATAATTTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT108561 WP_002482740.1 NZ_CP031196:864585-864878 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT108561 NZ_CP031196:864585-864878 [Staphylococcus saprophyticus]
ATGACTGAAATACAAAAAGCGCATCATTCAGAAGAAATAAAAGCAAATTTAAAATCAAGACTTAATAGAATCGAAGGTCA
AGTTAAAGCCATAAATCGTATGGTAGAGGAAGATGTGTACTGTGACGATGTGCTTACACAAATAAGAGCTACGCGATCCG
CATTAAATAGTGTCGCTACTAAATTATTAGATCATCATATGAAAAGTTGTATTATGGATAAAGTTGAACAGGGTCATGAA
CAAGAAGCGATGGAAGAACTACTTGTAACTTTTCAAAAATTGATGAAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References