Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 7695297..7695932 Replicon chromosome
Accession NZ_CP031168
Organism Paenibacillus sp. H1-7

Toxin (Protein)


Gene name pemK Uniprot ID A0A927LX01
Locus tag DVH26_RS33950 Protein ID WP_028553083.1
Coordinates 7695297..7695647 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DVH26_RS33955 Protein ID WP_239630023.1
Coordinates 7695651..7695932 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVH26_RS33915 (DVH26_34050) 7690368..7691036 + 669 WP_239630019.1 hypothetical protein -
DVH26_RS33930 (DVH26_34065) 7691454..7691927 - 474 WP_239630020.1 SprT family protein -
DVH26_RS33935 (DVH26_34070) 7692064..7692423 + 360 WP_239630021.1 hydrolase/acyltransferase -
DVH26_RS33940 (DVH26_34075) 7692635..7692778 + 144 WP_239630022.1 cortex morphogenetic protein CmpA -
DVH26_RS33945 (DVH26_34080) 7692887..7695112 - 2226 WP_275590489.1 Tex family protein -
DVH26_RS33950 (DVH26_34085) 7695297..7695647 - 351 WP_028553083.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DVH26_RS33955 (DVH26_34090) 7695651..7695932 - 282 WP_239630023.1 ribbon-helix-helix protein, CopG family Antitoxin
DVH26_RS33960 (DVH26_34095) 7696163..7697356 - 1194 WP_239630024.1 alanine racemase -
DVH26_RS33965 (DVH26_34100) 7698068..7699534 - 1467 WP_239630025.1 outer membrane lipoprotein carrier protein LolA -
DVH26_RS33970 (DVH26_34105) 7699648..7700583 - 936 WP_239630026.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-45)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12892.81 Da        Isoelectric Point: 4.8837

>T108558 WP_028553083.1 NZ_CP031168:c7695647-7695297 [Paenibacillus sp. H1-7]
MIVKRGDVFFADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAESHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDALQVSVGLIEF

Download         Length: 351 bp

>T108558 NZ_CP031168:c7695647-7695297 [Paenibacillus sp. H1-7]
TTGATTGTCAAACGAGGCGATGTGTTTTTTGCGGACTTGTCACCCGTCGTTGGGTCGGAGCAGGGCGGGATCCGGCCTGT
TCTCATTATTCAGAATGATATAGGGAATCGCTTCAGTCCTACGGTCATCGTGGCGGCGATCACAGCGCAAATTCAAAAAG
CCAAGCTGCCTACACACGTAGAAATTGATGCGGAGTCTCATGGCTTTGACAGGGATTCTGTCATTTTGCTGGAGCAAATT
CGTACGATTGATAAGCAGCGTCTGACAGATAAAATAACTCACCTTGACGAAGAGACGATGCGCAAAGTGGATGATGCATT
GCAGGTAAGCGTGGGACTGATTGAGTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10876.45 Da        Isoelectric Point: 6.4748

>AT108558 WP_239630023.1 NZ_CP031168:c7695932-7695651 [Paenibacillus sp. H1-7]
VSNAQNTKRIMISLPDYLLQEVDGIVEKENSNRSEFIRQAMKLYLMERKKRHLRESMQRGYMEMAKINLHMASEAFQAEE
EADNTLDRLVSGV

Download         Length: 282 bp

>AT108558 NZ_CP031168:c7695932-7695651 [Paenibacillus sp. H1-7]
GTGTCCAATGCGCAGAACACGAAACGAATAATGATCAGCTTGCCGGACTATTTGCTGCAAGAAGTGGACGGCATCGTGGA
GAAGGAGAACTCGAACCGCAGCGAGTTTATTCGTCAAGCGATGAAGCTGTACTTGATGGAACGGAAGAAACGCCATCTGA
GGGAATCGATGCAGCGCGGATATATGGAAATGGCGAAGATCAATTTACACATGGCCTCGGAGGCATTTCAGGCGGAGGAA
GAAGCGGATAACACTCTGGACCGTTTAGTAAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References