Detailed information of TA system TA108556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 99251..100834
• Replicon: chromosome
• Accession: NZ_CP031167
• Organism: Stenotrophomonas sp. ASS1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MG068_RS00420
• Protein ID: WP_107431360.1
• Coordinates: 99251..100573 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: M5CTC8
• Locus tag: MG068_RS00425
• Protein ID: WP_004134030.1
• Coordinates: 100577..100834 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MG068_RS00400	94566..96200	-	1635	WP_032128710.1	TldD/PmbA family protein	-
MG068_RS00405	96231..97862	-	1632	WP_165929912.1	TldD/PmbA family protein	-
MG068_RS00415	98636..99250	+	615	WP_132808723.1	DUF938 domain-containing protein	-
MG068_RS00420	99251..100573	-	1323	WP_107431360.1	type II toxin-antitoxin system HipA family toxin	Toxin
MG068_RS00425	100577..100834	-	258	WP_004134030.1	helix-turn-helix transcriptional regulator	Antitoxin
MG068_RS00430	100992..104678	-	3687	WP_132808725.1	indolepyruvate ferredoxin oxidoreductase family protein	-
MG068_RS00435	104847..105482	+	636	WP_032128715.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (19-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 48783.50 Da
• Isoelectric Point: 6.7182

>T108556 WP_107431360.1 NZ_CP031167:c100573-99251 [Stenotrophomonas sp. ASS1]
MGTLRVWMNGVEVALWDDARSGSSRLSYVDSWISSAQSRPLSLSLPLLPEGESHRGDVVNNYFDNLLPDNAVIRNRIRDR
FSTRSSDTFDLLEAIGRDCVGAVQLLPLSHTPGDIQQITCEALDESGVAAILRQVTAGNLPGAPTSDDAFRISIAGAQEK
TGLLLHAGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMQLLSAFGIPVANTQMGRFKDERALIVERFDRR
LSADRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVTIMDLLRQSEHFEDRATFFKTQILFWMLAATDGHAKNFSVYLE
AGGRFRLTPVYDVLSVHPILGRGPNQLDPRNAQLAMSVQGKNRHRKLHLVRRRHWNETARACGVADGAEPWIEALIAAVE
PAIEQVTRQLPSDFPVNVSEPIFNGLRAAAARLSSMSPDA

Nucleotide

• Length: 1323 bp

>T108556 NZ_CP031167:c100573-99251 [Stenotrophomonas sp. ASS1]
ATGGGTACGCTGCGGGTCTGGATGAATGGTGTCGAGGTCGCGCTCTGGGATGATGCCCGGAGCGGCTCTTCCCGGCTTTC
GTACGTCGACTCGTGGATCAGCTCCGCCCAGTCCCGGCCGTTGTCACTCTCACTGCCCCTGCTCCCGGAGGGTGAGAGCC
ATCGGGGCGATGTCGTCAACAACTACTTCGACAACCTTCTTCCCGACAACGCCGTCATCCGCAACCGGATCCGCGACAGG
TTCTCCACGCGCAGCAGCGACACGTTCGATCTTCTCGAAGCCATTGGCCGGGATTGCGTCGGCGCAGTGCAACTGCTGCC
GCTTTCGCATACACCGGGGGACATCCAGCAGATTACGTGCGAAGCGTTGGACGAATCAGGCGTCGCTGCGATCCTGCGTC
AGGTGACGGCAGGGAATCTACCTGGCGCACCCACCAGTGATGATGCGTTCCGCATATCCATCGCCGGTGCGCAGGAGAAG
ACGGGACTTCTGCTGCATGCTGGCCAGTGGTGCATTCCTACCGGCAGTACCCCATCCACCCACATCTTCAAGCTGCCGCT
TGGCATTGTGGGCAACATGCGGGCGGACATGCACCAATCCGTCGAGAACGAATGGCTGTGCATGCAACTGCTTTCCGCCT
TTGGAATCCCCGTTGCGAATACGCAGATGGGACGCTTCAAGGACGAACGCGCGCTTATTGTGGAGCGATTCGACCGCCGC
CTTTCTGCGGATCGCCGATGGTGGCTGCGGCTGCCGCAGGAAGACATGTGCCAGGTCTTCGGTCTGCCCGCTGCCAGGAA
GTATGAATCCGATGGCGGCCCAGGCATCGTGACCATCATGGATCTGCTTCGACAATCCGAGCATTTCGAGGATCGGGCGA
CCTTCTTCAAGACGCAGATTCTTTTCTGGATGTTGGCTGCAACCGATGGACATGCCAAGAACTTCAGTGTTTACCTCGAA
GCCGGTGGACGCTTCCGCCTGACACCCGTCTACGACGTATTGTCGGTGCATCCCATCCTGGGTAGGGGGCCAAACCAGCT
CGACCCGCGGAATGCACAGCTCGCCATGTCCGTCCAGGGCAAGAATCGCCACCGGAAGCTGCACCTTGTGCGACGACGCC
ATTGGAACGAAACCGCACGCGCCTGTGGTGTCGCTGATGGTGCGGAGCCGTGGATCGAAGCGCTGATCGCAGCCGTCGAA
CCCGCCATCGAGCAGGTCACGCGTCAGCTCCCAAGTGATTTCCCCGTAAACGTGTCCGAACCCATTTTCAACGGGCTGCG
CGCTGCGGCGGCACGCCTTTCCAGCATGTCGCCGGACGCCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9550.01 Da
• Isoelectric Point: 12.0740

>AT108556 WP_004134030.1 NZ_CP031167:c100834-100577 [Stenotrophomonas sp. ASS1]
MDRPLHTVRTPQQLAPLMRAFRRQAGLSQAQLAAQLGISRQAVGALERDPASASFERLMRVWAVLGLEVRLQQRSPPETT
STLEW

Nucleotide

• Length: 258 bp

>AT108556 NZ_CP031167:c100834-100577 [Stenotrophomonas sp. ASS1]
ATGGACAGGCCGCTGCACACGGTGAGGACACCTCAACAACTGGCACCGCTGATGCGTGCGTTCAGGCGCCAGGCGGGCCT
GAGCCAGGCGCAGTTGGCGGCACAGCTCGGCATAAGCCGCCAGGCAGTAGGCGCATTGGAGCGCGACCCGGCATCGGCAA
GCTTCGAACGGCTGATGCGGGTCTGGGCAGTGCTGGGTCTGGAAGTCAGATTGCAGCAGCGAAGCCCCCCGGAGACAACG
TCAACGTTGGAGTGGTGA

Structures

Antitoxin

• AlphaFold DB: M5CTC8