Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2249764..2250401 Replicon chromosome
Accession NZ_CP031158
Organism Deinococcus wulumuqiensis strain NEB 479

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DVJ83_RS11265 Protein ID WP_114672404.1
Coordinates 2250000..2250401 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DVJ83_RS11260 Protein ID WP_114672403.1
Coordinates 2249764..2250003 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVJ83_RS11235 2245411..2245638 + 228 WP_114672398.1 hypothetical protein -
DVJ83_RS11240 2245732..2246838 + 1107 WP_114672399.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -
DVJ83_RS11245 2246835..2247827 + 993 WP_114672400.1 alpha-ketoacid dehydrogenase subunit beta -
DVJ83_RS11250 2247848..2248096 + 249 WP_114672401.1 hypothetical protein -
DVJ83_RS11255 2248093..2249649 + 1557 WP_114672402.1 2-oxo acid dehydrogenase subunit E2 -
DVJ83_RS11260 2249764..2250003 + 240 WP_114672403.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DVJ83_RS11265 2250000..2250401 + 402 WP_114672404.1 PIN domain-containing protein Toxin
DVJ83_RS11270 2250401..2250718 + 318 WP_114672405.1 DUF4180 domain-containing protein -
DVJ83_RS11275 2250845..2252062 + 1218 WP_114672406.1 adenylosuccinate synthase -
DVJ83_RS11280 2252145..2252729 + 585 WP_114672407.1 GTP cyclohydrolase I FolE -
DVJ83_RS11285 2252789..2253328 + 540 WP_114672408.1 hypothetical protein -
DVJ83_RS11290 2253536..2254768 - 1233 WP_162865535.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2253536..2254759 1223


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-126)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14689.96 Da        Isoelectric Point: 7.0615

>T108552 WP_114672404.1 NZ_CP031158:2250000-2250401 [Deinococcus wulumuqiensis]
VSLTHLLDTKTCIYIINRRPPHVAEKFAQHAPDAVGLSSITLAELRYGVAKSGSAKNAAVLEAFIQPLEIVPFDAEATRH
YGPLRHVLQQQGRPIGAMDLLIAAHALALGVTLVTNNVKEFERVERLELENWF

Download         Length: 402 bp

>T108552 NZ_CP031158:2250000-2250401 [Deinococcus wulumuqiensis]
GTGAGCCTCACCCATCTGCTCGACACCAAGACCTGCATCTACATCATCAATCGCCGTCCGCCGCACGTCGCTGAAAAGTT
CGCCCAGCACGCCCCCGACGCGGTGGGACTGTCGAGTATCACGCTGGCCGAATTGCGCTACGGCGTCGCCAAAAGCGGGT
CGGCCAAAAATGCCGCCGTGCTCGAAGCGTTTATTCAGCCGTTGGAAATTGTCCCTTTTGATGCTGAGGCAACCCGGCAC
TACGGCCCGCTCCGTCACGTCTTGCAACAGCAGGGCCGACCTATCGGGGCGATGGATTTGCTGATTGCGGCGCACGCTTT
GGCTCTGGGGGTCACGCTGGTGACCAACAATGTCAAGGAATTCGAGCGGGTAGAGCGGCTTGAACTGGAGAACTGGTTTT
GA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9062.23 Da        Isoelectric Point: 4.7063

>AT108552 WP_114672403.1 NZ_CP031158:2249764-2250003 [Deinococcus wulumuqiensis]
MTTAKLFQTGRSQAVRLPKAFRFEGQEVTIKRVSNGVLLIPNTAEGQQEFWRGWYAALPEVDVPLTREDLPLQEQDWDS

Download         Length: 240 bp

>AT108552 NZ_CP031158:2249764-2250003 [Deinococcus wulumuqiensis]
ATGACGACAGCAAAACTTTTCCAGACGGGGCGTTCTCAAGCCGTGCGGCTGCCCAAAGCCTTCCGGTTCGAGGGACAGGA
AGTCACCATCAAGCGCGTCTCCAACGGGGTGCTGCTGATTCCCAATACCGCCGAGGGACAGCAGGAATTCTGGCGCGGCT
GGTACGCGGCCCTGCCTGAGGTGGACGTTCCGCTGACCCGTGAGGACTTGCCGCTGCAAGAGCAGGACTGGGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References