Detailed information of TA system TA108544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3603952..3604493
• Replicon: chromosome
• Accession: NZ_CP031145
• Organism: Intrasporangium calvum strain C5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DN585_RS16580
• Protein ID: WP_013494289.1
• Coordinates: 3603952..3604230 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: E6SG24
• Locus tag: DN585_RS16585
• Protein ID: WP_013494290.1
• Coordinates: 3604227..3604493 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3592869..3613837	20968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (31-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.80 Da
• Isoelectric Point: 10.3818

>T108544 WP_013494289.1 NZ_CP031145:c3604230-3603952 [Intrasporangium calvum]
VSEEPYELVLTPPAVRAVRSGLPEAVAAAVIEFLTGALIQNPHRVGKPLRGELAGIHSARRGTYRVLYRINEIQGEVVVL
RIDHRRDAYRRG

Nucleotide

• Length: 279 bp

>T108544 NZ_CP031145:c3604230-3603952 [Intrasporangium calvum]
GTGAGCGAAGAACCGTACGAACTGGTCCTGACCCCTCCCGCCGTCCGAGCCGTGCGCTCAGGACTGCCCGAGGCCGTTGC
GGCGGCGGTCATAGAGTTCCTCACCGGAGCATTGATCCAGAACCCGCACCGCGTCGGCAAGCCATTGCGGGGGGAGCTCG
CGGGTATCCACTCGGCCCGGCGCGGCACCTACCGCGTCCTGTATCGAATCAACGAGATCCAAGGCGAAGTGGTGGTTCTC
CGCATCGACCACCGACGAGACGCTTACCGACGCGGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9717.81 Da
• Isoelectric Point: 4.4325

>AT108544 WP_013494290.1 NZ_CP031145:c3604493-3604227 [Intrasporangium calvum]
MTVEPLRDVRNHFSDVIDRVEHEHERVTVTRNGRPVAVILSPDDLAQLEETLSVLSDPEALADIREADAAYATGDVVRGV
EAVRGLRS

Nucleotide

• Length: 267 bp

>AT108544 NZ_CP031145:c3604493-3604227 [Intrasporangium calvum]
ATGACTGTTGAACCGCTTCGCGATGTCCGCAACCATTTCAGCGACGTCATCGACCGCGTCGAGCATGAGCACGAGCGGGT
CACAGTCACGCGCAATGGACGCCCGGTTGCCGTCATCCTCAGCCCGGACGACCTGGCGCAGCTGGAGGAGACCCTCTCGG
TGCTCAGCGACCCCGAAGCCCTCGCCGACATCCGTGAGGCCGATGCGGCATACGCGACCGGTGACGTCGTTCGCGGGGTC
GAGGCCGTGCGCGGCCTGCGCTCGTGA

Structures

Antitoxin

• AlphaFold DB: E6SG24