Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 820964..821441 Replicon chromosome
Accession NZ_CP031131
Organism Staphylococcus aureus strain E16SA093

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag DU470_RS04100 Protein ID WP_000052076.1
Coordinates 820964..821152 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DU470_RS04105 Protein ID WP_001059690.1
Coordinates 821181..821441 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU470_RS04070 816954..817475 + 522 WP_000824484.1 hypothetical protein -
DU470_RS04075 817816..818502 + 687 WP_001792695.1 thermonuclease family protein -
DU470_RS04080 818859..819059 + 201 WP_001059082.1 cold-shock protein -
DU470_RS04085 819555..819773 - 219 WP_000005886.1 hypothetical protein -
DU470_RS04090 819835..820119 - 285 WP_001004395.1 hypothetical protein -
DU470_RS04095 820207..820776 - 570 WP_001106654.1 hypothetical protein -
DU470_RS04100 820964..821152 - 189 WP_000052076.1 hypothetical protein Toxin
DU470_RS04105 821181..821441 - 261 WP_001059690.1 hypothetical protein Antitoxin
DU470_RS04110 821782..821985 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DU470_RS04115 821982..822218 - 237 WP_000368687.1 hypothetical protein -
DU470_RS04120 822443..823024 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
DU470_RS04125 823097..823714 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
DU470_RS04130 823869..824363 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
DU470_RS04135 824762..825184 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
DU470_RS04140 825332..826048 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T108519 WP_000052076.1 NZ_CP031131:c821152-820964 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T108519 NZ_CP031131:c821152-820964 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT108519 WP_001059690.1 NZ_CP031131:c821441-821181 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT108519 NZ_CP031131:c821441-821181 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References