108512

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2114871..2115385 Replicon chromosome
Accession NZ_CP031130
Organism Staphylococcus aureus strain F17SA003

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DU471_RS10965 Protein ID WP_000581792.1
Coordinates 2114871..2115080 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DU471_RS10970 Protein ID WP_000138932.1
Coordinates 2115092..2115385 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU471_RS10945 2110379..2111737 - 1359 WP_000611470.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DU471_RS10950 2111752..2112822 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
DU471_RS10955 2113140..2114342 + 1203 WP_020978293.1 rod shape-determining protein RodA -
DU471_RS10960 2114606..2114743 - 138 WP_000828354.1 hypothetical protein -
DU471_RS10965 2114871..2115080 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DU471_RS10970 2115092..2115385 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DU471_RS10975 2115551..2117035 + 1485 WP_000571549.1 cardiolipin synthase -
DU471_RS10980 2117063..2117710 + 648 WP_001187630.1 HD domain-containing protein -
DU471_RS10990 2118182..2119054 - 873 WP_000725802.1 membrane protein insertase YidC -
DU471_RS10995 2119140..2119781 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T108512 WP_000581792.1 NZ_CP031130:c2115080-2114871 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T108512 NZ_CP031130:c2115080-2114871 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT108512 WP_000138932.1 NZ_CP031130:c2115385-2115092 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT108512 NZ_CP031130:c2115385-2115092 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References