Detailed information of TA system TA108511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2095130..2095659
• Replicon: chromosome
• Accession: NZ_CP031130
• Organism: Staphylococcus aureus strain F17SA003

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: DU471_RS10875
• Protein ID: WP_000621175.1
• Coordinates: 2095130..2095492 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: DU471_RS10880
• Protein ID: WP_000948331.1
• Coordinates: 2095489..2095659 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DU471_RS10850	2092109..2092879	-	771	WP_001041102.1	RNA polymerase sigma factor SigB	-
DU471_RS10855	2092854..2093333	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
DU471_RS10860	2093335..2093661	-	327	WP_001052491.1	anti-sigma factor antagonist	-
DU471_RS10865	2093780..2094781	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
DU471_RS10875	2095130..2095492	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
DU471_RS10880	2095489..2095659	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
DU471_RS10885	2095744..2096892	-	1149	WP_114604595.1	alanine racemase	-
DU471_RS10890	2096958..2097317	-	360	WP_000581197.1	holo-ACP synthase	-
DU471_RS10895	2097321..2097812	-	492	WP_001205910.1	PH domain-containing protein	-
DU471_RS10900	2097799..2099382	-	1584	WP_001294626.1	PH domain-containing protein	-
DU471_RS10905	2099375..2099854	-	480	WP_001287090.1	hypothetical protein	-
DU471_RS10910	2100063..2100623	-	561	WP_001092402.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T108511 WP_000621175.1 NZ_CP031130:c2095492-2095130 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T108511 NZ_CP031130:c2095492-2095130 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT108511 WP_000948331.1 NZ_CP031130:c2095659-2095489 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT108511 NZ_CP031130:c2095659-2095489 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1