Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 794831..795308 Replicon chromosome
Accession NZ_CP031130
Organism Staphylococcus aureus strain F17SA003

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag DU471_RS03975 Protein ID WP_000052076.1
Coordinates 794831..795019 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DU471_RS03980 Protein ID WP_001059690.1
Coordinates 795048..795308 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU471_RS03945 790821..791342 + 522 WP_000824484.1 hypothetical protein -
DU471_RS03950 791683..792369 + 687 WP_001792695.1 thermonuclease family protein -
DU471_RS03955 792726..792926 + 201 WP_001059082.1 cold-shock protein -
DU471_RS03960 793422..793640 - 219 WP_000005886.1 hypothetical protein -
DU471_RS03965 793702..793986 - 285 WP_001004395.1 hypothetical protein -
DU471_RS03970 794074..794643 - 570 WP_001106654.1 hypothetical protein -
DU471_RS03975 794831..795019 - 189 WP_000052076.1 hypothetical protein Toxin
DU471_RS03980 795048..795308 - 261 WP_001059690.1 hypothetical protein Antitoxin
DU471_RS03985 795649..795852 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DU471_RS03990 795849..796085 - 237 WP_000368687.1 hypothetical protein -
DU471_RS03995 796310..796891 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
DU471_RS04000 796964..797581 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
DU471_RS04005 797736..798230 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
DU471_RS04010 798629..799051 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
DU471_RS04015 799199..799915 + 717 WP_000150012.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T108503 WP_000052076.1 NZ_CP031130:c795019-794831 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T108503 NZ_CP031130:c795019-794831 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT108503 WP_001059690.1 NZ_CP031130:c795308-795048 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT108503 NZ_CP031130:c795308-795048 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References