Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2692393..2693033 Replicon chromosome
Accession NZ_CP031124
Organism Ephemeroptericola cinctiostellae strain F02

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DTO96_RS12420 Protein ID WP_114563799.1
Coordinates 2692857..2693033 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DTO96_RS12415 Protein ID WP_114563798.1
Coordinates 2692393..2692818 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTO96_RS12395 2688353..2689948 + 1596 WP_114564054.1 hypothetical protein -
DTO96_RS12400 2689945..2690124 + 180 WP_114563795.1 hypothetical protein -
DTO96_RS12405 2690121..2691491 + 1371 WP_114563796.1 hypothetical protein -
DTO96_RS12410 2691488..2692396 + 909 WP_114563797.1 hypothetical protein -
DTO96_RS12415 2692393..2692818 - 426 WP_114563798.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DTO96_RS12420 2692857..2693033 - 177 WP_114563799.1 mRNA interferase Toxin
DTO96_RS12425 2693183..2693755 + 573 WP_114563800.1 hypothetical protein -
DTO96_RS12710 2693983..2694234 + 252 WP_157964441.1 hypothetical protein -
DTO96_RS12430 2694407..2694607 + 201 WP_114563801.1 hypothetical protein -
DTO96_RS12435 2694862..2695269 + 408 WP_114563802.1 hypothetical protein -
DTO96_RS12440 2695406..2697982 + 2577 WP_114563803.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2681073..2722827 41754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-74)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6745.96 Da        Isoelectric Point: 11.0703

>T108500 WP_114563799.1 NZ_CP031124:c2693033-2692857 [Ephemeroptericola cinctiostellae]
MKISEFKRWLKQQGVEMIEGSKHTKLRVNGKQSHLPRHAAEIKEPLRKAILKQLGLND

Download         Length: 177 bp

>T108500 NZ_CP031124:c2693033-2692857 [Ephemeroptericola cinctiostellae]
ATGAAAATCAGCGAATTCAAACGGTGGCTTAAACAGCAAGGTGTGGAAATGATTGAAGGCTCTAAACACACCAAGTTGAG
GGTCAATGGCAAACAGAGTCATTTACCTCGTCATGCTGCCGAAATAAAAGAACCGTTGCGTAAGGCGATTTTAAAGCAAC
TCGGTTTAAACGATTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15494.89 Da        Isoelectric Point: 4.6647

>AT108500 WP_114563798.1 NZ_CP031124:c2692818-2692393 [Ephemeroptericola cinctiostellae]
MQTNNAYPIELIEDTGGYVVTFPDIPEAMTQGDTLAEALEMAQDVLLSAMDFYFEDKRAVPMPSKAKSGQYTVALPMSAW
AKVLLLNEVCAQQLRPIDVAHLMGTRPQYVNRILDLHHNTKIDTVAAALKAIGKDLTLGFA

Download         Length: 426 bp

>AT108500 NZ_CP031124:c2692818-2692393 [Ephemeroptericola cinctiostellae]
ATGCAAACCAATAACGCATATCCAATTGAATTGATTGAAGACACGGGCGGTTACGTGGTCACATTCCCCGACATTCCCGA
AGCGATGACACAGGGCGACACCTTGGCCGAAGCCCTCGAAATGGCGCAAGACGTTTTGTTGAGCGCAATGGATTTTTACT
TTGAGGATAAACGGGCTGTGCCAATGCCCTCCAAAGCCAAAAGCGGGCAATATACGGTTGCCTTACCCATGAGCGCATGG
GCGAAAGTATTGTTGCTCAATGAAGTGTGCGCCCAACAGCTGCGCCCGATTGACGTGGCGCATTTGATGGGTACGCGGCC
TCAGTATGTCAATCGCATTTTAGATTTGCACCATAACACCAAAATTGACACGGTGGCAGCAGCCTTAAAAGCAATCGGCA
AAGATTTAACCCTTGGGTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References