Detailed information of TA system TA108498

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 3643999..3644545
• Replicon: chromosome
• Accession: NZ_CP031123
• Organism: Providencia huaxiensis strain WCHPr000369

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CYG50_RS18565
• Protein ID: WP_102140618.1
• Coordinates: 3644264..3644545 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CYG50_RS18560
• Protein ID: WP_102140619.1
• Coordinates: 3643999..3644283 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYG50_RS18535	3639074..3640051	-	978	WP_004265237.1	6-phosphofructokinase	-
CYG50_RS18540	3640457..3641401	-	945	WP_102140623.1	phosphatidate cytidylyltransferase	-
CYG50_RS18545	3641398..3642039	-	642	WP_102140622.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
CYG50_RS18550	3642277..3643029	-	753	WP_004907010.1	M48 family metallopeptidase	-
CYG50_RS18555	3643256..3643837	-	582	WP_102140620.1	HutD family protein	-
CYG50_RS18560	3643999..3644283	+	285	WP_102140619.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
CYG50_RS18565	3644264..3644545	+	282	WP_102140618.1	type II toxin-antitoxin system YafQ family toxin	Toxin
CYG50_RS18570	3644905..3645636	+	732	WP_102140617.1	hypothetical protein	-
CYG50_RS18575	3645669..3645887	-	219	WP_102140616.1	ogr/Delta-like zinc finger family protein	-
CYG50_RS18580	3645959..3647056	-	1098	WP_116068830.1	phage late control D family protein	-
CYG50_RS18585	3647053..3647499	-	447	WP_102140831.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (9-84)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10908.76 Da
• Isoelectric Point: 8.8589

>T108498 WP_102140618.1 NZ_CP031123:3644264-3644545 [Providencia huaxiensis]
MLKIRVKSQFKKDLKKSLSDKKRNTQLLKELIDNHLCITGSVPAEYLPHPLKGNWRPCYECHIQPDFLLIWDINYQTNEI
ILVRCGSHSELFG

Nucleotide

• Length: 282 bp

>T108498 NZ_CP031123:3644264-3644545 [Providencia huaxiensis]
ATGCTGAAAATTCGCGTTAAATCCCAATTCAAAAAAGACTTAAAAAAGTCGTTATCTGACAAAAAAAGAAATACTCAGCT
ATTAAAAGAGTTAATCGATAACCACCTATGCATTACTGGCTCTGTTCCAGCAGAATATTTGCCTCATCCCTTAAAAGGAA
ACTGGAGACCTTGCTATGAATGTCACATACAACCCGATTTTTTATTAATTTGGGATATAAACTACCAAACCAATGAAATC
ATATTAGTTCGCTGTGGTTCTCATTCTGAATTATTTGGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10420.71 Da
• Isoelectric Point: 4.6412

>AT108498 WP_102140619.1 NZ_CP031123:3643999-3644283 [Providencia huaxiensis]
MASTQHKTDIVRARIEPKVRENAEAVLSELGISMSDAIRIFVKQISLRQAFPIELKTPNSITLEAINAPTTDETFDSAED
LFSQVSKSDAENSR

Nucleotide

• Length: 285 bp

>AT108498 NZ_CP031123:3643999-3644283 [Providencia huaxiensis]
ATGGCCAGTACTCAACATAAAACAGATATTGTCAGAGCCAGAATTGAGCCTAAAGTCAGGGAAAATGCTGAAGCAGTGTT
ATCTGAATTAGGGATTAGCATGTCTGATGCTATTCGTATTTTCGTCAAGCAAATATCATTGCGACAAGCTTTTCCTATTG
AGTTAAAAACACCAAACTCAATTACATTAGAAGCTATTAATGCACCAACTACAGACGAAACATTTGACTCTGCTGAAGAT
TTATTTAGCCAAGTGAGCAAGTCCGATGCTGAAAATTCGCGTTAA