Detailed information of TA system TA108497

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH
• Location: 3394300..3395032
• Replicon: chromosome
• Accession: NZ_CP031123
• Organism: Providencia huaxiensis strain WCHPr000369

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CYG50_RS17300
• Protein ID: WP_166264489.1
• Coordinates: 3394619..3395032 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: CYG50_RS17295
• Protein ID: WP_102138206.1
• Coordinates: 3394300..3394629 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CYG50_RS17275	3390269..3391240	-	972	WP_102138203.1	efflux RND transporter periplasmic adaptor subunit	-
CYG50_RS17285	3391874..3393559	+	1686	WP_102138263.1	sensor histidine kinase	-
CYG50_RS17290	3393579..3394295	+	717	WP_102138205.1	two-component system response regulator BtsR	-
CYG50_RS17295	3394300..3394629	-	330	WP_102138206.1	helix-turn-helix domain-containing protein	Antitoxin
CYG50_RS17300	3394619..3395032	-	414	WP_166264489.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CYG50_RS17305	3395162..3397102	-	1941	WP_102138207.1	DEAD/DEAH family ATP-dependent RNA helicase	-
CYG50_RS17310	3397273..3398139	-	867	WP_102138265.1	lipoprotein NlpI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (12-132)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-93)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15366.71 Da
• Isoelectric Point: 9.6258

>T108497 WP_166264489.1 NZ_CP031123:c3395032-3394619 [Providencia huaxiensis]
MSTTWRVVVAFYKISSFKRSTKKINIKDKQLLKAANEVLQGFYEADLGSGVIKKRIAINGKGKSGGIRVIIFFKASHHLF
FADGWDKSNISSKGAKEIAEDELDAYKGLSRLFLSYTDDKIADLVLCNILEELTDEQ

Nucleotide

• Length: 414 bp

>T108497 NZ_CP031123:c3395032-3394619 [Providencia huaxiensis]
ATGAGTACTACATGGAGAGTAGTTGTGGCGTTCTATAAAATTTCATCATTTAAGCGAAGCACTAAAAAAATCAATATAAA
AGATAAACAGTTACTTAAGGCTGCAAATGAAGTTTTACAGGGGTTTTATGAGGCAGACTTAGGGAGCGGTGTAATTAAAA
AAAGGATCGCGATTAATGGGAAAGGGAAAAGTGGTGGGATCAGAGTTATTATCTTCTTTAAAGCAAGCCACCATCTCTTT
TTTGCTGATGGGTGGGATAAAAGTAATATAAGTTCCAAAGGAGCAAAGGAAATTGCAGAAGATGAGTTAGATGCATATAA
GGGCCTATCTCGACTTTTTCTTAGCTATACGGATGATAAAATTGCTGATTTAGTTTTGTGTAATATTTTGGAGGAACTTA
CTGATGAGCAATAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12331.57 Da
• Isoelectric Point: 10.4252

>AT108497 WP_102138206.1 NZ_CP031123:c3394629-3394300 [Providencia huaxiensis]
MSNKLENMLELAKELHNVDAAPESLVNDLERKVRARNINKKIKVIPMMSGAQIKQLRAQYGMSQATLALVLGMSKESVSK
WEREEKKPSGPALRMLHLIEQRGPEILII

Nucleotide

• Length: 330 bp

>AT108497 NZ_CP031123:c3394629-3394300 [Providencia huaxiensis]
ATGAGCAATAAATTAGAAAACATGCTTGAGCTAGCTAAAGAATTACATAATGTTGATGCGGCACCAGAAAGTTTAGTTAA
TGATTTAGAAAGGAAAGTTAGAGCTCGAAATATAAATAAAAAAATAAAAGTTATACCTATGATGAGTGGTGCACAAATAA
AGCAACTCCGTGCTCAATATGGAATGTCGCAAGCAACATTAGCTTTAGTTTTAGGTATGTCTAAGGAAAGCGTTTCTAAG
TGGGAAAGAGAAGAAAAAAAACCCAGCGGCCCAGCTCTTCGCATGTTACATCTTATAGAGCAACGAGGGCCTGAGATTTT
AATTATTTAG