Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1481812..1482728 Replicon chromosome
Accession NZ_CP031123
Organism Providencia huaxiensis strain WCHPr000369

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag CYG50_RS08460 Protein ID WP_102140346.1
Coordinates 1481812..1482270 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag CYG50_RS08465 Protein ID WP_102140345.1
Coordinates 1482267..1482728 (-) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYG50_RS08435 1477352..1478818 + 1467 WP_102140351.1 AMP nucleosidase -
CYG50_RS08440 1478799..1479362 + 564 WP_102140350.1 GNAT family N-acetyltransferase -
CYG50_RS08445 1479393..1479815 + 423 WP_102140349.1 helix-turn-helix domain-containing protein -
CYG50_RS08450 1479920..1480879 + 960 WP_102140348.1 acetyl-CoA carboxylase carboxyl transferase subunit alpha -
CYG50_RS08455 1480921..1481811 + 891 WP_102140347.1 LysR family transcriptional regulator -
CYG50_RS08460 1481812..1482270 - 459 WP_102140346.1 RES domain-containing protein Toxin
CYG50_RS08465 1482267..1482728 - 462 WP_102140345.1 DUF2384 domain-containing protein Antitoxin
CYG50_RS08470 1482815..1483282 - 468 WP_102140344.1 DUF1456 family protein -
CYG50_RS08475 1483470..1483784 - 315 WP_102140343.1 AzlD domain-containing protein -
CYG50_RS08480 1483781..1484482 - 702 WP_102140342.1 AzlC family ABC transporter permease -
CYG50_RS08485 1484957..1485598 + 642 WP_102140341.1 leucine efflux protein LeuE -
CYG50_RS08490 1485859..1486125 + 267 WP_102140340.1 GntR family transcriptional regulator -
CYG50_RS08495 1486161..1486547 + 387 WP_202981455.1 cytidine deaminase -
CYG50_RS08500 1486604..1487077 + 474 WP_166267453.1 NUDIX domain-containing protein -
CYG50_RS08505 1487101..1487715 - 615 WP_102140337.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(38-95)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17153.77 Da        Isoelectric Point: 6.3188

>T108493 WP_102140346.1 NZ_CP031123:c1482270-1481812 [Providencia huaxiensis]
MILYRLVKSIFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDILLNQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPASTSTMDIGTTWLNNQDSLVLLIPSCIIPYEYNAIINPLHPQFQKAIRTVKPLDFSVDPRLA

Download         Length: 459 bp

>T108493 NZ_CP031123:c1482270-1481812 [Providencia huaxiensis]
ATGATCCTATATCGGTTGGTTAAATCCATTTTTGCTCACGATGCATGGTCGGGCCAAGGGGCTATGCTCTATGGTGGGCG
TTGGAATCATAAAGGGACTCCCGCTGTTTATACATCGACGAGTATTTCATTAGCAACCCTTGAAATACTCGTACACATCA
ATCAAGACATACTATTAAACCAGTTCAGTTTACTATCCATAGATATCAATGATAAGTACGTAATGAAATTGTCGTTAGAC
CACCTTCCAACGGATTGGCAGCAAGACCCAGCGTCAACCTCTACAATGGATATTGGCACTACATGGCTTAATAACCAAGA
TAGCTTAGTATTGTTAATTCCCTCTTGTATTATTCCCTATGAATACAACGCAATAATCAACCCGTTGCATCCGCAATTTC
AAAAAGCCATACGGACGGTTAAACCACTGGATTTTAGCGTTGATCCACGCTTAGCATAA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16968.38 Da        Isoelectric Point: 9.7275

>AT108493 WP_102140345.1 NZ_CP031123:c1482728-1482267 [Providencia huaxiensis]
MRNYIPTTPLQPAASASKPLWRHVGLPAERGIELTHYLRQGLSVSVLDNIQEWSGVSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Download         Length: 462 bp

>AT108493 NZ_CP031123:c1482728-1482267 [Providencia huaxiensis]
ATGAGAAACTATATCCCCACAACGCCGCTTCAACCCGCAGCTTCTGCTTCTAAGCCACTATGGCGCCATGTCGGGTTACC
CGCTGAAAGGGGTATTGAATTAACCCATTATTTACGTCAAGGCCTATCTGTCTCTGTCTTAGACAATATCCAAGAGTGGT
CAGGGGTGAGCAAAACAGAACTATTGCGGATATCTGGTATCAATGAACGCAATATCGCTCGTCGCAAAAATGCTGGCCAG
CCCCTAAATGCTGATGAAAGTGAACGAATTGCACGTCTAGTAAGGGTATTTGATGCCGCAGTGCGTTTATTTAATGGTGA
TAAACACGCAGCAAGTGATTGGCTCAATCACCCAGTGAAAGGCTTGGGTCATTTACGCCCTATTGAGCTTATCGCAACAG
AAAGCGGAGCCATTGAAGTGATTGATTTAATTGGCCGTATTGAACATGGTGTATTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References