Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 209085..209731 Replicon chromosome
Accession NZ_CP031123
Organism Providencia huaxiensis strain WCHPr000369

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag CYG50_RS02390 Protein ID WP_102139052.1
Coordinates 209085..209288 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag CYG50_RS02395 Protein ID WP_102139053.1
Coordinates 209363..209731 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CYG50_RS02365 205183..205521 + 339 WP_004905421.1 P-II family nitrogen regulator -
CYG50_RS02370 205571..206818 + 1248 WP_181490144.1 ammonium transporter AmtB -
CYG50_RS02375 206958..207827 - 870 WP_102139050.1 acyl-CoA thioesterase II -
CYG50_RS02380 208067..208525 + 459 WP_102139051.1 YbaY family lipoprotein -
CYG50_RS02390 209085..209288 - 204 WP_102139052.1 hemolysin expression modulator Hha Toxin
CYG50_RS02395 209363..209731 - 369 WP_102139053.1 Hha toxicity modulator TomB Antitoxin
CYG50_RS02400 210260..211630 - 1371 WP_102139054.1 murein transglycosylase D -
CYG50_RS02405 211712..212467 - 756 WP_102139055.1 hydroxyacylglutathione hydrolase -
CYG50_RS02410 212508..213242 + 735 WP_102139056.1 methyltransferase domain-containing protein -
CYG50_RS02415 213239..213709 - 471 WP_102139057.1 ribonuclease HI -
CYG50_RS02420 213764..214525 + 762 WP_102139069.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8121.44 Da        Isoelectric Point: 6.9770

>T108492 WP_102139052.1 NZ_CP031123:c209288-209085 [Providencia huaxiensis]
MTKFDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T108492 NZ_CP031123:c209288-209085 [Providencia huaxiensis]
ATGACCAAATTTGATTATCTGATGCGTTTAAGAAAATGTACAACAATTGAAACTCTTGAGCGTGTCATTGAAAAAAACAA
GTATGAATTATCTGATGATGAGCTAGAGCTATTCTACTCCGCAGCAGATCACCGCTTAGCTGAACTCACAATGAATAAGC
TTTATGATAAAATCCCAGCTTCTGTTTGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14033.99 Da        Isoelectric Point: 4.3849

>AT108492 WP_102139053.1 NZ_CP031123:c209731-209363 [Providencia huaxiensis]
MDEYSPKKHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEVIDWEAMNQSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT108492 NZ_CP031123:c209731-209363 [Providencia huaxiensis]
ATGGATGAATACTCACCCAAAAAACATGATATAGCAGAGCTAAAATACTTATGTAATAGCCTCAATAGAGATGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGACTTAAGCTCCCCTCAAAGCGCAGCCTTGAATGAGCTTATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATATCCAAAAGAGAATCTTGTTATATCACTTATCGAAGAGTACCTC
GATGAGACCTATGACTTATTCGGTAGCCCGGTCATCACGCTCAGTGAAGTTATAGACTGGGAAGCAATGAACCAGAGTCT
TGTCGCTGTGCTGGATGATGACCTAAAATGTCTAACCAGCAAAACCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References