Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1077057..1077737 Replicon chromosome
Accession NZ_CP031115
Organism Rubrobacter indicoceani strain SCSIO 08198

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DU509_RS05455 Protein ID WP_119067335.1
Coordinates 1077309..1077737 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DU509_RS05450 Protein ID WP_119067333.1
Coordinates 1077057..1077308 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU509_RS05420 1072123..1072878 - 756 WP_119070651.1 response regulator transcription factor -
DU509_RS05425 1072987..1073307 + 321 WP_119067325.1 hypothetical protein -
DU509_RS05430 1073339..1074145 + 807 WP_119067327.1 nitroreductase family protein -
DU509_RS05435 1074142..1075194 + 1053 WP_205544208.1 stilbene synthase -
DU509_RS05440 1075194..1075703 + 510 WP_119067329.1 hypothetical protein -
DU509_RS05445 1075777..1077060 + 1284 WP_119067331.1 serine--tRNA ligase -
DU509_RS05450 1077057..1077308 + 252 WP_119067333.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DU509_RS05455 1077309..1077737 + 429 WP_119067335.1 type II toxin-antitoxin system VapC family toxin Toxin
DU509_RS05460 1077734..1078681 + 948 WP_119067337.1 bile acid:sodium symporter family protein -
DU509_RS05465 1078758..1080188 + 1431 WP_119067339.1 proline--tRNA ligase -
DU509_RS05470 1080566..1081738 + 1173 WP_119067341.1 homoserine O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(7-45)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 14811.03 Da        Isoelectric Point: 4.1498

>T108490 WP_119067335.1 NZ_CP031115:1077309-1077737 [Rubrobacter indicoceani]
MDGKLLYLDPTAIVKLVVEAPETDALREELARWPERVTSRLSVAEVGREARLLYSEGAAVVAREVLSGLALVNVDAEVLR
LAADLELPGLPDPAGPPTLDVIHLATGLSLAGDFGAFVSYDGRMVLAADAAGLNVLVPGASP

Download         Length: 429 bp

>T108490 NZ_CP031115:1077309-1077737 [Rubrobacter indicoceani]
TTGGACGGGAAGCTTCTCTACCTAGACCCGACGGCGATCGTAAAGCTCGTGGTCGAGGCTCCGGAGACGGATGCGCTCCG
GGAAGAACTCGCCCGCTGGCCGGAGCGCGTTACGAGTCGGCTCTCCGTCGCGGAGGTCGGGCGTGAGGCGCGGCTGCTCT
ATTCGGAGGGGGCGGCGGTCGTTGCCCGCGAGGTTCTCTCTGGGCTCGCGCTCGTGAACGTAGACGCGGAGGTTCTGCGG
CTCGCCGCCGACCTCGAATTGCCGGGTCTGCCGGACCCGGCGGGCCCGCCGACGCTCGATGTCATCCACCTTGCGACCGG
GCTCTCGCTCGCGGGCGATTTCGGTGCGTTCGTCAGCTATGATGGCCGGATGGTACTCGCCGCCGACGCAGCCGGGCTCA
ACGTCCTTGTACCGGGGGCCTCCCCGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9056.17 Da        Isoelectric Point: 4.6538

>AT108490 WP_119067333.1 NZ_CP031115:1077057-1077308 [Rubrobacter indicoceani]
VSESREQVGVRELRQNLSRYLERVRAGEAFEVTERNRPVAVLAPLAGETTATGRLVAAGRGTAPTRDLLDVESLPVESLP
EEL

Download         Length: 252 bp

>AT108490 NZ_CP031115:1077057-1077308 [Rubrobacter indicoceani]
GTGAGCGAAAGCCGGGAACAGGTCGGGGTGCGGGAGCTGCGCCAGAACCTCAGCAGGTACCTTGAGCGGGTCCGGGCCGG
GGAGGCCTTCGAGGTCACGGAGCGCAACCGTCCGGTCGCCGTCCTTGCGCCGCTCGCCGGAGAGACGACCGCGACGGGGA
GGCTCGTCGCCGCCGGACGCGGCACCGCCCCGACGAGGGACCTGCTGGACGTGGAGTCGCTCCCGGTGGAGTCGCTCCCC
GAGGAACTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References