Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1310768..1312367 Replicon chromosome
Accession NZ_CP031112
Organism Bordetella pertussis strain UK38

Toxin (Protein)


Gene name hipA Uniprot ID Q7VVM6
Locus tag DVA62_RS06255 Protein ID WP_003816876.1
Coordinates 1311027..1312367 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DVA62_RS06250 Protein ID WP_019247974.1
Coordinates 1310768..1311025 (+) Length 86 a.a.

Genomic Context


DVA62_RS06240DVA62_RS06245DVA62_RS06250DVA62_RS06255DVA62_RS06265DVA62_RS20090DVA62_RS06275DVA62_RS06235DVA62_RS06260
Location: 1307265..1308725 (1461 bp)
Type: Others
Protein ID: WP_003812368.1
Location: 1308822..1310414 (1593 bp)
Type: Others
Protein ID: WP_010931040.1
Location: 1310768..1311025 (258 bp)
Type: Antitoxin
Protein ID: WP_019247974.1
Location: 1311027..1312367 (1341 bp)
Type: Toxin
Protein ID: WP_003816876.1
Location: 1313165..1314595 (1431 bp)
Type: Others
Protein ID: WP_019247976.1
Location: 1314827..1315905 (1079 bp)
Type: Others
Protein ID: Protein_1246
Location: 1316338..1317141 (804 bp)
Type: Others
Protein ID: WP_019248072.1
Location: 1306431..1307042 (612 bp)
Type: Others
Protein ID: WP_010931041.1
Location: 1312463..1313152 (690 bp)
Type: Others
Protein ID: WP_010931038.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DVA62_RS06235 (DVA62_06290)1306431..1307042-612WP_010931041.1DUF2239 family protein-
DVA62_RS06240 (DVA62_06295)1307265..1308725+1461WP_003812368.1IMP dehydrogenase-
DVA62_RS06245 (DVA62_06300)1308822..1310414+1593WP_010931040.1glutamine-hydrolyzing GMP synthase-
DVA62_RS06250 (DVA62_06310)1310768..1311025+258WP_019247974.1helix-turn-helix transcriptional regulatorAntitoxin
DVA62_RS06255 (DVA62_06315)1311027..1312367+1341WP_003816876.1type II toxin-antitoxin system HipA family toxinToxin
DVA62_RS06260 (DVA62_06320)1312463..1313152-690WP_010931038.1TetR/AcrR family transcriptional regulator-
DVA62_RS06265 (DVA62_06325)1313165..1314595+1431WP_019247976.1MFS transporter-
DVA62_RS20090 (DVA62_06330)1314827..1315905+1079Protein_1246tellurite resistance/C4-dicarboxylate transporter family protein-
DVA62_RS06275 (DVA62_06335)1316338..1317141+804WP_019248072.1IclR family transcriptional regulator-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(10-112)

Antitoxin

(18-70)


Sequences


Toxin        


Download         Length: 447 a.a.        Molecular weight: 49632.79 Da        Isoelectric Point: 7.4158

>T108481 WP_003816876.1 NZ_CP031112:1311027-1312367 [Bordetella pertussis]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

>T108481 NZ_CP031112:1311027-1312367 [Bordetella pertussis]
ATGGGGCGCCGATCGCACAGCCGCAGCCTGTCCATCTGGACCAACGGCGTTCGCGTCGGGCGTTGGACGGTTCCCGCTCG
CGGAGAGATGGAACTGCAGTACGACGTGGATTGGGTCCGTGCCGACGTCGGCCGGCCACTTTCGCTGTCGCTGCCATTCA
ACTTGCAGAATCTGCCCCTCAAGGGGGAGAGAGTCGCCAACTACTTCGACAATCTGCTACCGGACAGCGACGCTATCCGT
CGTCGCGTGGCCGAGCGATTCAGGACGGGCTCGGTCGATCCCTTCGATCTGTTGAAAGCCATTGGACGCGATTGCGTTGG
CGCCGTACAGATCCTGGAAGACGAAGAGATACCTGAGGGCTTTGATCGCATCGAGGGCGTGCCTCTGTCCGAGGAGGACA
TCGAGCGGCATTTGATCGAAACCGTTACGCCGCGCGCCTTCGCTGCGGGCCGGGACCCGGACGCGGATTTCAGAATTTCT
CTGGCCGGCGCGCAAGAGAAGACAGCCTTCCTGTGGTGGGGCGGACAGTGGCTTGCGCCGCGTGGCGCGACATCGACGAG
CCATATTTTCAAACTTCCATTGGGCTTGGTGGGTGGACGGCGGGCTGACTTCAGCACTTCTGTTGATAACGAATGGCTGT
GTCTGAAGCTGCTGAAGGCGTATGGGTTGGATGTGGCTGAGGCCAGCATCGCAACCTTCGGACAGCAGCGAGTGCTGGTG
GTCGAGCGATTCGACCGGCGTGTTGCGCCCAACGGGCAATGGCTGATGCGCCTGCCGCAGGAAGATTTCTGCCAGGTCGA
GGGGTGCTCGCCGCTACGCAAGTATGAAAACGAGGGCGGCCCAGGACTCAAGGCCTTATTCGCCACGCTGCGGCAGTCAG
TGAACGCAGCGGTCGATATGAGAACGTTGATGGCGGCGCAGATCCTGTTTTGGTTGCTGCGGGCACCCGATGGCCACGCC
AAGAATTTCAGCATCCAGTTGTTGCCGCGCGGCCGTTTCCAGTTGACTAGACTGTACGACGTGATGTCGGCCTATCCGGT
ACTGGGCGATGGCGCGAATCAGTGGTCGCCGTTCGAAATCAAATTGGCGATGGCATTGATTGGCAAGAACCGGCATTACG
AGATGCACGGCATCCAGCGCAGGCACTTCAACAGCACCGCACAAAAAGTTGGTTATGGCCCGACGGCGGAGCCGATCATT
GAAGACCTGTTGGCCCGTACGCCCGCGATCATTGCCGCCGTGCAGGCCGATTTGCCGCAGGACTTCTCGCCGCGTGTTGC
GGACTCCGTCCTGGGTGGGCTTGCGCAGGCCGCAAAGTCGCTCGGCGCAATGATGCCGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT108481 WP_019247974.1 NZ_CP031112:1310768-1311025 [Bordetella pertussis]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp

>AT108481 NZ_CP031112:1310768-1311025 [Bordetella pertussis]
ATGCCGCCGCCATCACAACCTCTGCTCACTACCGGCCAGCTTGGCGCGGTCTTGCAGGCTGCACGCAAAGCACAGGGACT
GACTCAATCGGCCCTGGCCAGTCGTATCGGCCTGAGCCAATCGCGGGTCTCGCACCTGGAGTTGAATGCCCATCAACTGA
GCGTGGAGCAGCTCCTGGCCTGGTGCGCGGCGCTAGGGTTGGAGTTGACGATTGCGACTCGCGGAAGTCCCGCAGGGTCT
TCCGACGCGGATTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBQ7VVM6


Antitoxin

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Source
ID
Structure
No matching records found

References