Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 4865346..4866078 Replicon chromosome
Accession NZ_CP031104
Organism Leclercia sp. W6

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag DVA43_RS23900 Protein ID WP_114316983.1
Coordinates 4865346..4865675 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag DVA43_RS23905 Protein ID WP_114316984.1
Coordinates 4865713..4866078 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA43_RS23880 4862027..4862581 - 555 WP_114316979.1 YceI family protein -
DVA43_RS23885 4862792..4863481 + 690 WP_114316980.1 N-acetylmannosamine-6-phosphate 2-epimerase -
DVA43_RS23890 4863697..4864698 + 1002 WP_114316981.1 zinc-binding alcohol dehydrogenase family protein -
DVA43_RS23895 4864715..4865005 + 291 WP_168194696.1 antibiotic biosynthesis monooxygenase -
DVA43_RS23900 4865346..4865675 - 330 WP_114316983.1 TA system toxin CbtA family protein Toxin
DVA43_RS23905 4865713..4866078 - 366 WP_114316984.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DVA43_RS23910 4866104..4866325 - 222 WP_072050100.1 DUF987 family protein -
DVA43_RS23915 4866322..4866864 - 543 WP_105455437.1 DNA repair protein RadC -
DVA43_RS23920 4866877..4867320 - 444 WP_045413291.1 antirestriction protein -
DVA43_RS23925 4867351..4868172 - 822 WP_114316985.1 DUF945 domain-containing protein -
DVA43_RS23930 4868265..4868606 - 342 WP_114316986.1 hypothetical protein -
DVA43_RS23935 4868641..4869105 - 465 WP_114316987.1 hypothetical protein -
DVA43_RS23945 4869231..4869389 - 159 WP_045413303.1 hypothetical protein -
DVA43_RS23950 4869602..4870489 - 888 WP_168194678.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12353.00 Da        Isoelectric Point: 8.5569

>T108433 WP_114316983.1 NZ_CP031104:c4865675-4865346 [Leclercia sp. W6]
MQTLSSHPTRATQPNLSPVETWQRLLTHLLSQQYGLTLNDTPFSNETAIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISIVDILQARRSTGLLKTNVK

Download         Length: 330 bp

>T108433 NZ_CP031104:c4865675-4865346 [Leclercia sp. W6]
ATGCAAACCTTATCATCACACCCGACACGGGCGACTCAGCCCAATCTGTCACCCGTTGAAACCTGGCAACGGCTGCTAAC
TCATCTTTTATCGCAGCAATATGGCCTGACGTTGAATGACACACCGTTCAGTAATGAAACCGCCATACGAGAACATATTG
ATGCTGGAGTATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATACGGGCTTGTCCGTATCGACCGAAAGGGATTT
TCGTGGCAAGAACAAACCCCGTATATTTCCATAGTGGATATTCTGCAAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13438.21 Da        Isoelectric Point: 6.8215

>AT108433 WP_114316984.1 NZ_CP031104:c4866078-4865713 [Leclercia sp. W6]
MNNHSKSGTKPENPACQQWGLKRTITPCFGARLVQEGNRVHFLADRAGFNGTFSDNDALRLDQAFPLILKQLELMLTSGE
LSHLHQHCITLYHNGLTCEADTLGSCGYVYIAIYPGQPEPH

Download         Length: 366 bp

>AT108433 NZ_CP031104:c4866078-4865713 [Leclercia sp. W6]
ATGAACAATCACTCCAAATCCGGTACCAAGCCGGAGAATCCCGCCTGCCAGCAGTGGGGACTAAAGCGCACAATCACACC
CTGTTTTGGCGCTCGTCTGGTGCAGGAAGGCAACCGGGTGCATTTTCTCGCTGACAGGGCCGGATTCAACGGTACTTTCA
GCGACAACGATGCATTGCGCCTCGACCAGGCCTTTCCGTTGATACTCAAACAACTGGAGTTGATGCTCACCAGCGGAGAA
CTCTCTCACCTGCATCAGCACTGCATCACGCTATACCACAATGGACTGACTTGCGAAGCTGACACACTCGGCTCCTGTGG
CTATGTCTACATCGCTATTTATCCCGGCCAGCCTGAACCCCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References