108431

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3742274..3742890 Replicon chromosome
Accession NZ_CP031104
Organism Leclercia sp. W6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DVA43_RS18300 Protein ID WP_114316356.1
Coordinates 3742519..3742890 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DVA43_RS18295 Protein ID WP_023618112.1
Coordinates 3742274..3742516 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA43_RS18265 3737406..3738302 + 897 WP_114316353.1 sugar kinase -
DVA43_RS18270 3738337..3739137 + 801 WP_103825285.1 DeoR/GlpR family DNA-binding transcription regulator -
DVA43_RS18275 3739257..3739856 + 600 WP_103825284.1 glucose-1-phosphatase -
DVA43_RS18280 3739850..3740731 + 882 WP_114316354.1 virulence factor BrkB family protein -
DVA43_RS18285 3740728..3741165 + 438 WP_103177564.1 D-tyrosyl-tRNA(Tyr) deacylase -
DVA43_RS18290 3741210..3742148 + 939 WP_168194667.1 fatty acid biosynthesis protein FabY -
DVA43_RS18295 3742274..3742516 + 243 WP_023618112.1 ribbon-helix-helix protein, CopG family Antitoxin
DVA43_RS18300 3742519..3742890 + 372 WP_114316356.1 type II toxin-antitoxin system VapC family toxin Toxin
DVA43_RS18305 3742930..3743859 - 930 WP_114316357.1 formate dehydrogenase accessory protein FdhE -
DVA43_RS18310 3743856..3744491 - 636 WP_032615363.1 formate dehydrogenase cytochrome b556 subunit -
DVA43_RS18315 3744488..3745390 - 903 WP_103825279.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13622.77 Da        Isoelectric Point: 6.9792

>T108431 WP_114316356.1 NZ_CP031104:3742519-3742890 [Leclercia sp. W6]
VEHMAVFDTNILIDLFNNRVEAADTIDRTAAHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDITREIAERSVLLR
EKHGMKLPDAIILATAQSRNCPLISRNTKDFAGIAGVISPYQL

Download         Length: 372 bp

>T108431 NZ_CP031104:3742519-3742890 [Leclercia sp. W6]
GTGGAACACATGGCAGTGTTTGATACCAATATTCTCATCGATCTCTTTAACAATCGTGTTGAAGCGGCGGATACGATCGA
TCGTACCGCAGCGCATCGTGCTATCAGCTTAATTACCTGGATGGAAGTCATGGTTGGGGCTCGTAGGCACGGTCATGAGG
CGAAAACGGCGGCAGTTATGGGCGCTTTCGAGATTATCGATATTACGCGTGAGATTGCTGAAAGAAGTGTATTGCTCCGC
GAGAAGCATGGGATGAAACTTCCTGATGCCATTATTCTGGCCACAGCTCAGAGCAGAAACTGCCCGTTAATTTCTCGCAA
TACCAAAGACTTTGCAGGTATAGCAGGGGTGATTTCGCCCTATCAACTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9427.72 Da        Isoelectric Point: 4.3224

>AT108431 WP_023618112.1 NZ_CP031104:3742274-3742516 [Leclercia sp. W6]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLKNQPRAELLREAIELYLDQQSSSIIRDALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT108431 NZ_CP031104:3742274-3742516 [Leclercia sp. W6]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGGTTGGATAACCT
CAAGCAGCTAAAAAATCAGCCGCGTGCTGAACTGCTGCGGGAAGCCATAGAGCTGTACCTCGACCAACAGAGTTCTTCGA
TTATCCGCGATGCGCTTGGCCTGTGGGGAGATCGCAAAGAGGATGGGCTGGAGTATGAGCGTAAGCTGCGCGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References