Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 3604219..3604880 Replicon chromosome
Accession NZ_CP031104
Organism Leclercia sp. W6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DVA43_RS17630 Protein ID WP_114316294.1
Coordinates 3604219..3604617 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DVA43_RS17635 Protein ID WP_103824281.1
Coordinates 3604614..3604880 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA43_RS17610 3600217..3601305 + 1089 WP_114316290.1 AAA family ATPase -
DVA43_RS17615 3601325..3602287 - 963 WP_114316291.1 helix-turn-helix domain-containing protein -
DVA43_RS17620 3602313..3603092 - 780 WP_114316292.1 MBL fold metallo-hydrolase -
DVA43_RS17625 3603220..3604023 - 804 WP_114316293.1 lipoprotein NlpA -
DVA43_RS17630 3604219..3604617 - 399 WP_114316294.1 type II toxin-antitoxin system VapC family toxin Toxin
DVA43_RS17635 3604614..3604880 - 267 WP_103824281.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DVA43_RS17640 3604998..3606497 - 1500 WP_114316295.1 MFS transporter -
DVA43_RS17645 3606576..3607235 + 660 WP_114316296.1 TetR/AcrR family transcriptional regulator -
DVA43_RS17650 3607232..3607651 - 420 WP_114316297.1 GNAT family N-acetyltransferase -
DVA43_RS24750 3607796..3607972 - 177 WP_168194666.1 hypothetical protein -
DVA43_RS17655 3607971..3608267 + 297 WP_103177671.1 hypothetical protein -
DVA43_RS17660 3608304..3609251 - 948 WP_103824277.1 LacI family transcriptional regulator -
DVA43_RS17665 3609546..3609860 + 315 WP_103824276.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14701.87 Da        Isoelectric Point: 6.8714

>T108430 WP_114316294.1 NZ_CP031104:c3604617-3604219 [Leclercia sp. W6]
MKHMLDTNIVSHLFKRHPGVVNRMTNLKPADVCISSITEAELLYGADKKQSTRLKETIKTFLSTITIYDWDSDAAAAYGK
LRAEMETRGKVMADLDQLIAAHAISRGTTIVTNDRAFGMVQELTIEDWTTAA

Download         Length: 399 bp

>T108430 NZ_CP031104:c3604617-3604219 [Leclercia sp. W6]
ATGAAACATATGCTGGATACAAATATTGTGAGCCATTTATTTAAAAGGCATCCCGGTGTTGTAAATAGAATGACTAACCT
GAAGCCAGCGGACGTATGTATCTCAAGTATCACAGAAGCGGAGCTGCTTTATGGGGCGGATAAAAAACAAAGCACCAGGT
TAAAAGAGACCATAAAGACGTTTCTGAGCACTATCACTATCTATGACTGGGACAGTGACGCCGCAGCCGCTTACGGCAAA
CTCCGTGCTGAGATGGAAACTCGAGGTAAAGTGATGGCAGATCTTGATCAGTTGATCGCAGCCCATGCCATTAGCCGGGG
CACAACGATTGTGACTAACGATCGTGCTTTCGGAATGGTACAGGAGTTGACTATCGAGGACTGGACTACAGCGGCGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10125.47 Da        Isoelectric Point: 4.8896

>AT108430 WP_103824281.1 NZ_CP031104:c3604880-3604614 [Leclercia sp. W6]
MERKAKLFKKGQNQAVLLPAEFAFDAESVWIRRDEEGNVVLAAKPAKEKSWDEFFRMLENTTVPDSFLSPEERNQSITKR
DPLDGVQV

Download         Length: 267 bp

>AT108430 NZ_CP031104:c3604880-3604614 [Leclercia sp. W6]
ATGGAACGTAAAGCAAAACTGTTCAAAAAAGGGCAAAACCAGGCGGTTTTACTGCCTGCTGAGTTCGCGTTTGATGCGGA
GAGTGTCTGGATCCGGCGGGATGAAGAGGGGAATGTGGTTCTGGCTGCAAAACCTGCCAAGGAAAAAAGCTGGGATGAAT
TTTTCAGGATGTTGGAAAACACCACCGTACCTGATTCATTTTTAAGTCCGGAGGAAAGAAATCAGAGTATTACAAAGAGG
GATCCCCTGGATGGAGTTCAGGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References