Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3555999..3556718 Replicon chromosome
Accession NZ_CP031104
Organism Leclercia sp. W6

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1B7K7P6
Locus tag DVA43_RS17310 Protein ID WP_023336519.1
Coordinates 3556398..3556718 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1B7K7N3
Locus tag DVA43_RS17305 Protein ID WP_023336520.1
Coordinates 3555999..3556364 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA43_RS17270 3552363..3552797 + 435 WP_023336527.1 hypothetical protein -
DVA43_RS17275 3552817..3553620 + 804 WP_023336526.1 hypothetical protein -
DVA43_RS17285 3553865..3554305 + 441 WP_064540881.1 hypothetical protein -
DVA43_RS17290 3554377..3555198 + 822 WP_038859440.1 DUF945 domain-containing protein -
DVA43_RS17295 3555267..3555737 + 471 WP_023336522.1 DNA repair protein RadC -
DVA43_RS17300 3555746..3555967 + 222 WP_023336521.1 DUF987 domain-containing protein -
DVA43_RS17305 3555999..3556364 + 366 WP_023336520.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DVA43_RS17310 3556398..3556718 + 321 WP_023336519.1 TA system toxin CbtA family protein Toxin
DVA43_RS24570 3557066..3558040 + 975 WP_147271039.1 hypothetical protein -
DVA43_RS17320 3558125..3558298 - 174 WP_114316252.1 DUF3950 domain-containing protein -
DVA43_RS17325 3558560..3558778 - 219 WP_114316253.1 ogr/Delta-like zinc finger family protein -
DVA43_RS17330 3558838..3559938 - 1101 WP_114316254.1 phage late control D family protein -
DVA43_RS17335 3559938..3560399 - 462 WP_114316255.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaD 3490443..3591961 101518


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-104)

Antitoxin

Antitoxin CbeA

(18-115)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12166.88 Da        Isoelectric Point: 5.9559

>T108429 WP_023336519.1 NZ_CP031104:3556398-3556718 [Leclercia sp. W6]
MHIPTVPATVTVSSRLSPVQIWQKLLTYLLEHHYGLTINDTPFSNDTAILEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWLTPLDVHRAQFTLGLKRS

Download         Length: 321 bp

>T108429 NZ_CP031104:3556398-3556718 [Leclercia sp. W6]
ATGCATATTCCAACTGTACCGGCAACGGTGACGGTTTCGTCACGCCTATCTCCTGTCCAGATTTGGCAAAAACTATTAAC
GTATCTTTTAGAGCATCATTACGGCCTCACGATCAACGACACACCGTTCAGTAACGATACGGCGATTCTGGAACATATAG
AGGCGGGAGTGAATCTTACTGATGCTGTTAATTTCCTTGTAGAACGATTCGAGCTTGTGCGCATTGACCAGAAGGGTTTC
TCCTGGCAGGATCAAGAACCCTGGCTAACACCTTTGGATGTTCATCGGGCACAGTTCACCCTTGGCTTGAAACGCTCATA
A

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13481.16 Da        Isoelectric Point: 6.0592

>AT108429 WP_023336520.1 NZ_CP031104:3555999-3556364 [Leclercia sp. W6]
MQSTTLSGTSAENASCFQWGLKRNITPCFGARLVQEGNRLYFLADRAGFNGSFSDEEALRLDQAFPLMMKQLEQMLTTGE
LDPSSQHCVTRHHNGLTCEADTLGSHGYVYIAIYPWSALTR

Download         Length: 366 bp

>AT108429 NZ_CP031104:3555999-3556364 [Leclercia sp. W6]
ATGCAGTCGACCACCTTATCCGGCACATCGGCGGAGAACGCATCCTGCTTTCAGTGGGGATTAAAACGTAATATCACGCC
ATGCTTCGGCGCTCGCCTGGTACAGGAAGGCAACCGCTTATACTTTCTGGCTGACCGGGCAGGATTTAATGGCTCATTCA
GTGACGAAGAAGCTTTGCGTCTGGACCAGGCATTTCCACTGATGATGAAACAGCTTGAGCAGATGCTGACCACTGGCGAG
CTTGATCCCAGCAGCCAGCACTGCGTCACACGGCATCACAACGGACTTACTTGTGAAGCTGACACTCTCGGCTCTCATGG
CTACGTTTACATCGCCATATATCCCTGGTCAGCTCTAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7K7P6

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7K7N3

References