Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) KacT-ataR/DUF1778(antitoxin)
Location 3067447..3068241 Replicon chromosome
Accession NZ_CP031104
Organism Leclercia sp. W6

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag DVA43_RS14985 Protein ID WP_103823102.1
Coordinates 3067720..3068241 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag DVA43_RS14980 Protein ID WP_103823103.1
Coordinates 3067447..3067716 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA43_RS14960 3064020..3065099 - 1080 WP_103823107.1 DUF2955 domain-containing protein -
DVA43_RS14965 3065102..3066169 - 1068 WP_103823106.1 HlyD family secretion protein -
DVA43_RS14970 3066169..3066636 - 468 WP_114315995.1 MarR family transcriptional regulator -
DVA43_RS14975 3066733..3067122 - 390 WP_114315996.1 hypothetical protein -
DVA43_RS14980 3067447..3067716 + 270 WP_103823103.1 DUF1778 domain-containing protein Antitoxin
DVA43_RS14985 3067720..3068241 + 522 WP_103823102.1 GNAT family N-acetyltransferase Toxin
DVA43_RS14990 3068294..3068989 - 696 WP_114315997.1 winged helix-turn-helix domain-containing protein -
DVA43_RS14995 3068964..3069359 - 396 WP_114315998.1 amino acid-binding protein -
DVA43_RS15000 3069352..3069675 - 324 WP_103823099.1 antibiotic biosynthesis monooxygenase -
DVA43_RS15005 3069912..3071327 - 1416 WP_114315999.1 aldehyde dehydrogenase family protein -
DVA43_RS15010 3071428..3072252 + 825 WP_168194661.1 LysR family transcriptional regulator -
DVA43_RS15015 3072317..3072796 - 480 WP_114316000.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19442.43 Da        Isoelectric Point: 9.5128

>T108428 WP_103823102.1 NZ_CP031104:3067720-3068241 [Leclercia sp. W6]
VTKLTIRMFSHEARYDLTDFNCGDSTLNRFLFDHLARQHSGRLLRAYLLVTDAPEPKVLGYYTLSGSCFEKETLPSKTQQ
RKVPYVNVPSVTLGRLAIHQDFQGQGWGMTLVTHAMKVVYLASQAVGIHGMFVDALNDKAKAFYLKLGFISLTGSNANSL
FYPTKSIEKLFVE

Download         Length: 522 bp

>T108428 NZ_CP031104:3067720-3068241 [Leclercia sp. W6]
GTGACTAAACTGACGATAAGGATGTTTTCGCATGAGGCACGCTATGATTTAACAGACTTCAACTGCGGGGATAGCACCCT
GAACCGCTTTCTGTTCGATCACCTTGCACGCCAACACAGCGGGCGCCTGCTACGCGCCTATCTTCTTGTCACCGATGCCC
CTGAGCCAAAAGTGCTGGGTTACTATACGTTGTCCGGCAGTTGCTTTGAGAAAGAGACACTGCCCTCAAAAACGCAGCAG
CGCAAAGTACCGTACGTCAATGTGCCCAGCGTCACGTTAGGACGTCTCGCTATACATCAGGATTTTCAGGGCCAGGGCTG
GGGGATGACGCTGGTGACCCATGCCATGAAAGTGGTCTACCTGGCCTCACAGGCCGTTGGCATTCACGGTATGTTTGTGG
ATGCACTCAACGATAAAGCGAAAGCGTTTTATCTCAAGCTCGGCTTTATCTCGCTAACCGGCAGCAATGCCAACTCTCTT
TTTTATCCTACAAAATCAATCGAGAAGCTGTTTGTTGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10334.68 Da        Isoelectric Point: 4.8839

>AT108428 WP_103823103.1 NZ_CP031104:3067447-3067716 [Leclercia sp. W6]
MSALKKQRIDLRLTEEDKDLIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLILNENSWNRVMDALDNPPEPNDQLKR
AAKRLQNME

Download         Length: 270 bp

>AT108428 NZ_CP031104:3067447-3067716 [Leclercia sp. W6]
ATGTCAGCACTGAAAAAACAGCGCATCGACCTCAGGTTAACGGAAGAAGACAAGGATCTGATCGAAGAGGCTGCGGCGAT
GACTAACCAGACAATTACCCAGTTTATGGTTAACAGTGCCTCTGAACGTGCTGCAGAAGTCATTGAGCAGCATCGTCGTC
TCATCCTCAATGAAAATTCGTGGAACCGGGTGATGGATGCGCTCGACAATCCGCCAGAGCCGAACGACCAGCTGAAACGC
GCAGCGAAACGCTTACAAAACATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References