Detailed information of TA system TA108426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2551584..2552203
• Replicon: chromosome
• Accession: NZ_CP031104
• Organism: Leclercia sp. W6

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A345CDT0
• Locus tag: DVA43_RS12545
• Protein ID: WP_032616864.1
• Coordinates: 2551985..2552203 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: DVA43_RS12540
• Protein ID: WP_114315744.1
• Coordinates: 2551584..2551976 (+)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVA43_RS12530	2546737..2547930	+	1194	WP_103824067.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
DVA43_RS12535	2547953..2551093	+	3141	WP_103178504.1	multidrug efflux RND transporter permease subunit AcrB	-
DVA43_RS12540	2551584..2551976	+	393	WP_114315744.1	Hha toxicity modulator TomB	Antitoxin
DVA43_RS12545	2551985..2552203	+	219	WP_032616864.1	hemolysin expression modulator Hha	Toxin
DVA43_RS12550	2552469..2552933	+	465	WP_114315745.1	YlaC family protein	-
DVA43_RS12555	2552984..2553124	-	141	WP_003859006.1	type B 50S ribosomal protein L36	-
DVA43_RS12560	2553382..2554950	+	1569	WP_114315746.1	EAL domain-containing protein	-
DVA43_RS12565	2554983..2555336	-	354	WP_103824063.1	DUF1428 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-115)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8583.95 Da
• Isoelectric Point: 8.9008

>T108426 WP_032616864.1 NZ_CP031104:2551985-2552203 [Leclercia sp. W6]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Nucleotide

• Length: 219 bp

>T108426 NZ_CP031104:2551985-2552203 [Leclercia sp. W6]
ATGTCTGATAAACCATTAACCAAGACTGATTATTTGATGCGTTTGCGACGCTGTCAGTCCATTGACACCCTCGAACGCGT
CATTGAAAAAAATAAATACGAGCTTTCTGATAATGAGCTTGCGGTATTCTATTCAGCAGCCGATCATCGCCTGGCTGAAC
TTACGATGAATAAGCTGTACGATAAAATCCCAACTGCTGTATGGAAGTTTGTACGCTGA

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 15228.12 Da
• Isoelectric Point: 4.8941

>AT108426 WP_114315744.1 NZ_CP031104:2551584-2551976 [Leclercia sp. W6]
MDEYSPKRQDFAQLKFLCESLYHDCLTNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNASRANPLVSPVKIITNN

Nucleotide

• Length: 393 bp

>AT108426 NZ_CP031104:2551584-2551976 [Leclercia sp. W6]
ATGGACGAATACTCGCCCAAAAGGCAAGATTTTGCACAGTTGAAATTCCTTTGTGAATCCCTGTACCATGACTGCCTGAC
CAATCTCGATGAAAGCAACCATGGCTGGGTAAATGACCCTACTTCTGCCATTAATTTGCAGTTAAACGAGTTGATTGAGC
ATATTGCTACCTTCGCGCTTAATTATAAAATTAAGTATAACGAAGATAATAAGTTGATTGAGCAGATTGACGAATACCTG
GATGACACTTTTATGTTATTCAGTAGCTACGGCATTAACACACAGGATTTACAAAAATGGCGTAAATCTGGCAATCGGCT
TTTTCGTTGTTTTGTCAATGCGAGTAGAGCTAATCCGTTAGTTTCTCCGGTTAAAATTATTACAAACAATTAG

Structures

Toxin

• AlphaFold DB: A0A345CDT0