Detailed information of TA system TA108425

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipB(antitoxin)
• Location: 1325867..1326351
• Replicon: chromosome
• Accession: NZ_CP031104
• Organism: Leclercia sp. W6

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: DVA43_RS24465
• Protein ID: WP_147271012.1
• Coordinates: 1326211..1326351 (+)
• Length: 47 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: DVA43_RS06405
• Protein ID: WP_103824398.1
• Coordinates: 1325867..1326118 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVA43_RS06400	1321260..1325051	-	3792	WP_114317089.1	glycosyltransferase	-
DVA43_RS06405	1325867..1326118	+	252	WP_103824398.1	helix-turn-helix domain-containing protein	Antitoxin
DVA43_RS24465	1326211..1326351	+	141	WP_147271012.1	type II toxin-antitoxin system HipA family toxin	Toxin
DVA43_RS06410	1326457..1327518	+	1062	WP_114314967.1	YncE family protein	-
DVA43_RS06415	1327529..1329523	+	1995	WP_114314968.1	TonB-dependent receptor	-
DVA43_RS06420	1329657..1330838	+	1182	WP_114314969.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5111.78 Da
• Isoelectric Point: 4.5148

>T108425 WP_147271012.1 NZ_CP031104:1326211-1326351 [Leclercia sp. W6]
MKEMADRTDEVIATVRAELPTDFPEQISGAIFRGLASQAARISRFD

Nucleotide

• Length: 141 bp

>T108425 NZ_CP031104:1326211-1326351 [Leclercia sp. W6]
ATGAAAGAGATGGCCGACCGCACGGATGAAGTAATCGCCACCGTCAGGGCGGAATTGCCGACGGATTTTCCAGAACAGAT
AAGCGGGGCGATTTTCCGCGGTCTGGCAAGCCAGGCGGCGAGAATAAGCCGCTTCGATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9267.57 Da
• Isoelectric Point: 8.6819

>AT108425 WP_103824398.1 NZ_CP031104:1325867-1326118 [Leclercia sp. W6]
MKVTTAGALAQAVRDQRKVNKLTQSETAEQVGIKQTTVSDFENKPESTKLETLFKILAALDLELHVVKRGSTLPDNPSWT
KEW

Nucleotide

• Length: 252 bp

>AT108425 NZ_CP031104:1325867-1326118 [Leclercia sp. W6]
ATGAAAGTAACAACGGCAGGTGCACTGGCACAGGCAGTCAGAGATCAGCGTAAGGTCAATAAGTTAACGCAATCGGAGAC
CGCTGAACAGGTTGGCATTAAACAAACTACGGTATCGGATTTCGAGAACAAACCTGAATCCACCAAGCTGGAAACCTTGT
TCAAAATTCTCGCGGCGCTGGATCTGGAACTCCATGTGGTGAAAAGAGGGTCGACGCTGCCCGATAACCCCAGCTGGACA
AAGGAGTGGTAA