Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1253692..1254266 Replicon chromosome
Accession NZ_CP031104
Organism Leclercia sp. W6

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag DVA43_RS06115 Protein ID WP_103822010.1
Coordinates 1253692..1254018 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag DVA43_RS06120 Protein ID WP_114314922.1
Coordinates 1254018..1254266 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA43_RS06095 1249399..1250091 + 693 WP_114314918.1 ABC transporter ATP-binding protein -
DVA43_RS06100 1250088..1251056 + 969 WP_114314919.1 ABC transporter substrate-binding protein -
DVA43_RS06105 1251095..1252750 + 1656 WP_114314920.1 iron ABC transporter permease -
DVA43_RS06110 1252820..1253665 + 846 WP_114314921.1 N-hydroxyarylamine O-acetyltransferase -
DVA43_RS06115 1253692..1254018 - 327 WP_103822010.1 endoribonuclease MazF Toxin
DVA43_RS06120 1254018..1254266 - 249 WP_114314922.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DVA43_RS06125 1254449..1255129 - 681 WP_103179651.1 respiratory nitrate reductase subunit gamma -
DVA43_RS06130 1255126..1255821 - 696 WP_114314923.1 nitrate reductase molybdenum cofactor assembly chaperone -
DVA43_RS06135 1255821..1257365 - 1545 WP_114314924.1 nitrate reductase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hcp/tssD 1244352..1254266 9914


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 11867.58 Da        Isoelectric Point: 7.8553

>T108424 WP_103822010.1 NZ_CP031104:c1254018-1253692 [Leclercia sp. W6]
MDYIPEAGDIVWLDFDPQSGHEQAGHRPALVISPASYNGRTGLMLCCPLTSQIKNYPFEVAISGSRRNVALADQIKNLDW
RARNAVKKGTATAEELDAVRMRAKVLIG

Download         Length: 327 bp

>T108424 NZ_CP031104:c1254018-1253692 [Leclercia sp. W6]
ATGGACTACATCCCGGAAGCGGGTGATATCGTCTGGCTGGATTTTGATCCGCAGTCAGGACATGAACAGGCAGGTCACCG
CCCTGCACTGGTTATTTCACCCGCCAGCTACAATGGACGCACCGGTTTGATGCTCTGCTGTCCACTCACATCGCAAATCA
AAAACTACCCCTTCGAAGTGGCTATTAGCGGTTCGCGCCGCAACGTCGCCCTTGCGGATCAGATCAAAAATCTGGACTGG
CGGGCGCGAAACGCTGTGAAAAAGGGAACAGCCACCGCCGAAGAGCTGGATGCCGTGAGAATGCGCGCTAAGGTTTTAAT
CGGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9128.38 Da        Isoelectric Point: 4.3431

>AT108424 WP_114314922.1 NZ_CP031104:c1254266-1254018 [Leclercia sp. W6]
MPQVTVKKWGNSPSVRLPVAVMREAELNVDDVVNVNVDEEGRIILTPVKRDEPTLESLLAAITDDNLHHEITFGEPQGKE
LL

Download         Length: 249 bp

>AT108424 NZ_CP031104:c1254266-1254018 [Leclercia sp. W6]
ATGCCGCAGGTCACCGTTAAAAAATGGGGGAACAGTCCTTCTGTCAGGCTTCCCGTCGCGGTTATGCGTGAGGCAGAACT
GAACGTAGACGATGTGGTAAATGTTAATGTCGACGAAGAGGGACGGATAATTTTGACACCGGTAAAAAGGGACGAACCGA
CGCTGGAATCGCTGCTCGCGGCAATTACTGACGACAATCTGCATCACGAAATCACATTTGGAGAACCGCAAGGCAAGGAG
CTGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References