Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-RHH
Location 4720635..4721251 Replicon chromosome
Accession NZ_CP031101
Organism Leclercia sp. W17

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DVA44_RS23335 Protein ID WP_114388319.1
Coordinates 4720635..4721006 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DVA44_RS23340 Protein ID WP_114388320.1
Coordinates 4721009..4721251 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DVA44_RS23320 4718135..4719037 + 903 WP_103825279.1 formate dehydrogenase subunit beta -
DVA44_RS23325 4719034..4719669 + 636 WP_032615363.1 formate dehydrogenase cytochrome b556 subunit -
DVA44_RS23330 4719666..4720595 + 930 WP_114388318.1 formate dehydrogenase accessory protein FdhE -
DVA44_RS23335 4720635..4721006 - 372 WP_114388319.1 PIN domain-containing protein Toxin
DVA44_RS23340 4721009..4721251 - 243 WP_114388320.1 ribbon-helix-helix domain-containing protein Antitoxin
DVA44_RS23345 4721452..4721655 + 204 Protein_4445 alpha/beta hydrolase -
DVA44_RS23350 4721965..4722525 + 561 WP_114388321.1 Ail/Lom family outer membrane beta-barrel protein -
DVA44_RS23355 4722594..4723535 - 942 WP_032615389.1 fatty acid biosynthesis protein FabY -
DVA44_RS23360 4723580..4724017 - 438 WP_103177564.1 D-tyrosyl-tRNA(Tyr) deacylase -
DVA44_RS23365 4724014..4724895 - 882 WP_114316354.1 virulence factor BrkB family protein -
DVA44_RS23370 4724889..4725488 - 600 WP_114388322.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13579.71 Da        Isoelectric Point: 6.9790

>T108412 WP_114388319.1 NZ_CP031101:c4721006-4720635 [Leclercia sp. W17]
VEHMAVFDTNILIDLFNNRIEAANAIESAASHRTISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDITREIAERSVLLR
EKHGMKLPDAIILATAQNRNCPLISRNTKDFAGIAGVVSPYQL

Download         Length: 372 bp

>T108412 NZ_CP031101:c4721006-4720635 [Leclercia sp. W17]
GTGGAACACATGGCGGTGTTTGATACCAATATTCTCATCGATCTCTTTAATAACCGGATTGAAGCTGCAAATGCAATTGA
AAGTGCTGCGTCGCACCGGACTATTAGCCTCATCACCTGGATGGAAGTCATGGTAGGGGCTCGCAGGCACGGTCATGAGG
CGAAAACGGCGGCAGTTATGGGCGCTTTCGAGATTATCGATATTACGCGTGAGATTGCTGAAAGAAGTGTATTGCTCCGC
GAGAAGCATGGGATGAAACTTCCTGATGCCATTATTCTGGCCACAGCTCAGAACAGAAACTGCCCGTTAATTTCACGCAA
TACCAAAGACTTTGCAGGTATAGCAGGGGTGGTTTCGCCCTATCAACTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9426.60 Da        Isoelectric Point: 4.2342

>AT108412 WP_114388320.1 NZ_CP031101:c4721251-4721009 [Leclercia sp. W17]
MSLSVNIDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIEQYLDQQSVSVIRDALGLWGNQQEDGLDYERKLREEW

Download         Length: 243 bp

>AT108412 NZ_CP031101:c4721251-4721009 [Leclercia sp. W17]
ATGAGTTTATCGGTGAATATTGATATGGGCAGAATACTGATCGATTTGTCGGATGACGTTATTCAGCGGCTCGATAATCT
GAAGCAGCTGCGGAACCAGCCGCGCGCTGAATTATTACGGGAAGCAATAGAGCAGTATCTCGATCAACAGAGTGTCTCGG
TCATTCGTGATGCGCTGGGTCTATGGGGTAACCAGCAAGAAGACGGGCTTGACTACGAACGTAAGCTACGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References