Detailed information of TA system TA108411

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): KacT-ataR/DUF1778(antitoxin)
• Location: 4235081..4235875
• Replicon: chromosome
• Accession: NZ_CP031101
• Organism: Leclercia sp. W17

Toxin (Protein)

• Gene name: KacT
• Uniprot ID: -
• Locus tag: DVA44_RS21040
• Protein ID: WP_114388041.1
• Coordinates: 4235354..4235875 (+)
• Length: 174 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: DVA44_RS21035
• Protein ID: WP_103823103.1
• Coordinates: 4235081..4235350 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DVA44_RS21015	4231654..4232733	-	1080	WP_114388038.1	DUF2955 domain-containing protein	-
DVA44_RS21020	4232736..4233803	-	1068	WP_114388039.1	HlyD family secretion protein	-
DVA44_RS21025	4233803..4234270	-	468	WP_114315995.1	MarR family transcriptional regulator	-
DVA44_RS21030	4234367..4234756	-	390	WP_114388040.1	hypothetical protein	-
DVA44_RS21035	4235081..4235350	+	270	WP_103823103.1	DUF1778 domain-containing protein	Antitoxin
DVA44_RS21040	4235354..4235875	+	522	WP_114388041.1	GNAT family N-acetyltransferase	Toxin
DVA44_RS21045	4235928..4236623	-	696	WP_114388042.1	winged helix-turn-helix domain-containing protein	-
DVA44_RS21050	4236598..4236993	-	396	WP_114388043.1	amino acid-binding protein	-
DVA44_RS21055	4236986..4237309	-	324	WP_114388044.1	antibiotic biosynthesis monooxygenase	-
DVA44_RS21060	4237482..4238897	-	1416	WP_114388045.1	aldehyde dehydrogenase family protein	-
DVA44_RS21065	4238998..4239900	+	903	WP_103823097.1	LysR family transcriptional regulator	-
DVA44_RS21070	4239887..4240366	-	480	WP_114316000.1	carboxymuconolactone decarboxylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (83-150)

Antitoxin

• Vibrio phage ICP1, Orf50 (8-86)

Sequences

Toxin

Protein

• Length: 174 a.a.
• Molecular weight: 19433.39 Da
• Isoelectric Point: 8.6498

>T108411 WP_114388041.1 NZ_CP031101:4235354-4235875 [Leclercia sp. W17]
VTKLTIRMFSHEARYDLTDFNCGDSTLNRFLFDHLACQHSGRLLRAYLLVTDDPEPKVLGYYTLSGSCFEKETLPSKTQQ
RKVPYVNVPSVTLGRLAIHQDFQGQGWGMTLVTHAMKVVYLASQAVGIHGMFVDALNDKAKAFYLKLGFISLTGSNANSL
FYPTKSIEKLFVE

Nucleotide

• Length: 522 bp

>T108411 NZ_CP031101:4235354-4235875 [Leclercia sp. W17]
GTGACTAAACTGACGATAAGGATGTTTTCGCATGAGGCACGCTATGATTTAACAGACTTCAATTGCGGGGATAGCACCCT
GAATCGTTTTCTGTTCGATCACCTTGCATGCCAACACAGCGGGCGCCTGCTACGCGCCTATCTTCTTGTCACCGATGACC
CTGAGCCAAAAGTGCTGGGTTACTATACGTTGTCCGGCAGTTGCTTTGAGAAAGAGACACTGCCCTCAAAAACGCAGCAG
CGCAAAGTGCCGTACGTCAATGTGCCCAGCGTCACGTTAGGACGTCTCGCCATACATCAGGATTTCCAGGGACAGGGCTG
GGGGATGACGCTGGTGACCCATGCCATGAAAGTGGTCTACCTGGCCTCACAGGCCGTTGGCATTCACGGCATGTTTGTGG
ATGCACTCAACGATAAAGCGAAAGCGTTTTATCTCAAGCTCGGCTTTATTTCGCTAACCGGCAGCAATGCCAACTCTCTT
TTTTATCCTACAAAATCAATCGAGAAGCTGTTTGTTGAGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10334.68 Da
• Isoelectric Point: 4.8839

>AT108411 WP_103823103.1 NZ_CP031101:4235081-4235350 [Leclercia sp. W17]
MSALKKQRIDLRLTEEDKDLIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLILNENSWNRVMDALDNPPEPNDQLKR
AAKRLQNME

Nucleotide

• Length: 270 bp

>AT108411 NZ_CP031101:4235081-4235350 [Leclercia sp. W17]
ATGTCAGCACTGAAAAAACAGCGCATCGACCTCAGGTTAACGGAAGAAGACAAGGATCTGATCGAAGAGGCTGCGGCGAT
GACTAACCAGACAATTACCCAGTTTATGGTTAACAGTGCCTCTGAACGTGCTGCAGAAGTCATTGAGCAGCATCGTCGTC
TCATCCTCAATGAAAATTCGTGGAACCGGGTGATGGATGCGCTCGACAATCCGCCAGAGCCGAACGACCAGCTGAAACGC
GCAGCGAAACGCTTACAAAACATGGAGTAA